PUBLICATION
Cadherin-16 regulates acoustic sensory gating in zebrafish through endocrine signaling
- Authors
- Schloss, S.S., Marshall, Z.Q., Santistevan, N.J., Gjorcheska, S., Stenzel, A., Barske, L., Nelson, J.C.
- ID
- ZDB-PUB-250503-4
- Date
- 2025
- Source
- PLoS Biology 23: e3003164e3003164 (Journal)
- Registered Authors
- Barske, Lindsey
- Keywords
- none
- MeSH Terms
-
- Signal Transduction
- Reflex, Startle/physiology
- Calcium/metabolism
- Zebrafish*/metabolism
- Zebrafish*/physiology
- Animals
- Homeostasis
- Cadherins*/genetics
- Cadherins*/metabolism
- Cadherins*/physiology
- Sensory Gating*/physiology
- Zebrafish Proteins*/genetics
- Zebrafish Proteins*/metabolism
- Larva
- PubMed
- 40315416 Full text @ PLoS Biol.
Citation
Schloss, S.S., Marshall, Z.Q., Santistevan, N.J., Gjorcheska, S., Stenzel, A., Barske, L., Nelson, J.C. (2025) Cadherin-16 regulates acoustic sensory gating in zebrafish through endocrine signaling. PLoS Biology. 23:e3003164e3003164.
Abstract
Sensory thresholds enable animals to regulate their behavioral responses to environmental threats. Despite the importance of sensory thresholds for animal behavior and human health, we do not yet have a full appreciation of the underlying molecular-genetic and circuit mechanisms. The larval zebrafish acoustic startle response provides a powerful system to identify molecular mechanisms underlying establishment of sensory thresholds and plasticity of thresholds through mechanisms like habituation. Using this system, we identify Cadherin-16 as a previously undescribed regulator of sensory gating. We demonstrate that Cadherin-16 regulates sensory thresholds via an endocrine organ, the corpuscle of Stannius (CS), which is essential in zebrafish for regulating Ca2+ homeostasis. We further show that Cadherin-16 regulates whole-body calcium and ultimately behavior through the hormone Stanniocalcin 1l (Stc1l), and the IGF-regulatory metalloprotease, Papp-aa. Finally, we demonstrate the importance of the CS through ablation experiments that reveal its role in promoting normal acoustic sensory gating. Together, our results uncover a previously undescribed brain non-autonomous pathway for the regulation of behavior and underscore Ca2+ homeostasis as a critical process underlying sensory gating in vivo.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping