Gene
met
- ID
- ZDB-GENE-041014-1
- Name
- MET proto-oncogene, receptor tyrosine kinase
- Symbol
- met Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable hepatocyte growth factor receptor activity. Acts upstream of or within several processes, including exocrine pancreas development; nervous system development; and pectoral fin development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Is expressed in several structures, including anterior neural rod; endocrine system; gut; musculature system; and nervous system. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); distal arthrogryposis; and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7153684 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 29 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh533 | Allele with one delins | Unknown | Unknown | CRISPR | |
| fh534 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la028683Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| pc36 | Allele with one delins | Unknown | Unknown | zinc finger nuclease | |
| s908 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa16304 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17944 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18672 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24650 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44271 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 97 | Alliance | ?Deafness, autosomal recessive 97 | 616705 |
| hepatocellular carcinoma | Alliance | Hepatocellular carcinoma, childhood type, somatic | 114550 |
| papillary renal cell carcinoma | Alliance | Renal cell carcinoma, papillary, 1, familial and somatic | 605074 |
| ?Arthrogryposis, distal, type 11 | 620019 | ||
| {Osteofibrous dysplasia, susceptibility to} | 607278 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001627 | Sema domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Plexin family | Plexin repeat | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | PSI domain | Sema domain | Sema domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, HGF/MSP receptor | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q64GK4 | InterPro | 1382 | ||||||||||||||||
| UniProtKB:F1QLR7 | InterPro | 1382 | ||||||||||||||||
| UniProtKB:A0A8M2BA12 | InterPro | 1335 |
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Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-4.9sox10:dnmet-IRES-EGFP,cryaa:EGFP) |
| 1 | Ali et al., 2021 | ||
| Tg(met:GAL4,UAS:EGFP) |
|
| 1 | (9) | |
| Tg(met:mCherry-2A-KALTA4) |
|
| 1 | (4) | |
| Tg(olig1:dnmet-IRES-EGFP,cryaa:EGFP) |
| 1 | Ali et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-226K23 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7153684 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007124 (1) | 4157 nt | ||
| Genomic | GenBank:DP000237 (1) | 468356 nt | ||
| Polypeptide | UniProtKB:F1QLR7 (1) | 1382 aa |
- Fang, Y., Wan, J.P., Wang, Z., Song, S.Y., Zhang, C.X., Yang, L., Zhang, Q.Y., Yan, C.Y., Wu, F.Y., Lu, S.Y., Sun, F., Han, B., Zhao, S.X., Dong, M., Song, H.D. (2024) Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion. Nature communications. 15:31653165
- Ren, M., Chen, X., Dai, L., Tu, J., Hu, H., Sun, X., Luo, J., Li, P., Fu, Y., Zhu, Y., Sun, W., Tang, Z., Liu, M., Ren, X., Lu, Q. (2024) Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish. Biomedicines. 13:
- Lu, F., Leach, L.L., Gross, J.M. (2023) A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium. Scientific Reports. 13:31423142
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
- Tao, Z., Yang, D., Ni, R. (2023) Tmed10 deficiency results in impaired exocrine pancreatic differentiation in zebrafish larvae. Developmental Biology. 503:43-52
- Dong, R., Zhang, Y., Chen, S., Wang, H., Hu, K., Zhao, H., Tian, Q., Zeng, K., Wang, S., Han, L. (2022) Identification of key pharmacodynamic markers of American ginseng against heart failure based on metabolomics and zebrafish model. Frontiers in pharmacology. 13:909084
- Ali, M.F., Latimer, A.J., Wang, Y., Hogenmiller, L., Fontenas, L., Isabella, A.J., Moens, C.B., Yu, G., Kucenas, S. (2021) Met is required for oligodendrocyte progenitor cell migration in Danio rerio. G3 (Bethesda). 11(10):
- Cavone, L., McCann, T., Drake, L.K., Aguzzi, E.A., Oprişoreanu, A.M., Pedersen, E., Sandi, S., Selvarajah, J., Tsarouchas, T.M., Wehner, D., Keatinge, M., Mysiak, K.S., Henderson, B.E.P., Dobie, R., Henderson, N.C., Becker, T., Becker, C.G. (2021) A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord. Developmental Cell. 56(11):1617-1630.e6
- Chiang, K.Y., Li, Y.W., Li, Y.H., Huang, S.J., Wu, C.L., Gong, H.Y., Wu, J.L. (2021) Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish. International Journal of Molecular Sciences. 22(20):
- Hatzold, J., Wessendorf, H., Pogoda, H.M., Bloch, W., Hammerschmidt, M. (2021) The Kunitz-type serine protease inhibitor Spint2 is required for cellular cohesion, coordinated cell migration and cell survival during zebrafish hatching gland development. Developmental Biology. 476:148-170
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