Gene

six1a

ID
ZDB-GENE-040718-155
Name
SIX homeobox 1a
Symbol
six1a Nomenclature History
Previous Names
  • six1b (1)
  • six2
  • zgc:92332 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within regulation of inner ear receptor cell differentiation; regulation of skeletal muscle cell proliferation; and skeletal muscle fiber development. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including anterior migratory muscle precursor stream; middle migratory muscle precursor stream; musculature system; nervous system; and posterior migratory muscle precursor stream. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 23; branchiootorenal syndrome; and nephroblastoma. Orthologous to human SIX1 (SIX homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la011534TgTransgenic insertionUnknownUnknownDNA
oz8Allele with one delinsUnknownFrameshiftCRISPR
oz9Allele with one insertionUnknownUnknownCRISPR
sa17539Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
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Human Disease
Associated With six1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 23 Alliance Deafness, autosomal dominant 23 605192
branchiootic syndrome Alliance Branchiootic syndrome 3 608389
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Associated With six1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR008422 KN homeodomain
Domain IPR031701 Homeobox protein SIX1, N-terminal SD domain
Homologous_superfamily IPR009057 Homedomain-like superfamily
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Domain Details Per Protein
Protein Additional Resources Length Homedomain-like superfamily Homeobox, conserved site Homeobox protein SIX1, N-terminal SD domain Homeodomain KN homeodomain
UniProtKB:A0A8M9QFC5 InterPro 283
UniProtKB:Q6DHF9 InterPro 283
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 13
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA six1a-201 (1) Ensembl 1,573 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-202M24ZFIN Curated Data
EncodesESTIMAGE:7154851Thisse et al., 2004
EncodescDNAMGC:92332ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanSIX114
Amino acid sequence comparison (1)
Phylogenetic tree (1)
Conserved genome location (synteny) (1)
MouseSix112
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
Citations
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