Gene
msgn1
- ID
- ZDB-GENE-030722-1
- Name
- mesogenin 1
- Symbol
- msgn1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within paraxial mesodermal cell differentiation; regulation of transcription by RNA polymerase II; and somatic muscle development. Predicted to be active in nucleus. Is expressed in several structures, including margin; mesoderm; myoblast; tail bud; and telencephalon. Orthologous to human MSGN1 (mesogenin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109769 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh273 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| msgn1_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa33349 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-msgn1 | Saunders et al., 2023 | |
| CRISPR2-msgn1 | Saunders et al., 2023 | |
| MO1-msgn1 | N/A | (5) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Mesogenin/MesP | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|---|
| UniProtKB:Q90ZL1 | InterPro | 131 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:HA-msgn1,Xla.Cryg:ECFP) |
|
| 1 | (2) | |
| Tg(hsp70l:msgn1-2A-NLS-KikGR) |
| 1 | (2) | ||
| Tg(msgn1:Cre-ERT2) |
|
| 1 | (5) | |
| Tg(msgn1:GAL4-VP16) |
|
| 1 | Yabe et al., 2023 | |
| Tg(msgn1:NLS-Kaede) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-222H17 | ZFIN Curated Data | |
| Contained in | BAC | CH211-249I14 | ZFIN Curated Data | |
| Encodes | EST | fc39h09 | ||
| Encodes | EST | wz13339 | ||
| Encodes | cDNA | MGC:109769 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174017 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192585 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_182882 (1) | 1724 nt | ||
| Genomic | GenBank:BX890562 (1) | 195554 nt | ||
| Polypeptide | UniProtKB:Q90ZL1 (1) | 131 aa |
- Koparir, A., Lekszas, C., Keseroglu, K., Rose, T., Rappl, L., Rad, A., Maroofian, R., Narendran, N., Hasanzadeh, A., Karimiani, E.G., Boschann, F., Kornak, U., Klopocki, E., Özbudak, E.M., Vona, B., Haaf, T., Liedtke, D. (2024) Zebrafish as a model to investigate a biallelic gain-of-function variant in MSGN1, associated with a novel skeletal dysplasia syndrome. Human genomics. 18:2323
- Labudina, A.A., Meier, M., Gimenez, G., Tatarakis, D., Ketharnathan, S., Mackie, B., Schilling, T.F., Antony, J., Horsfield, J.A. (2024) Cohesin composition and dosage independently affect early development in zebrafish. Development (Cambridge, England). 151(15):
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
- Yabe, T., Uriu, K., Takada, S. (2023) Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation. Nature communications. 14:21152115
- Ikeda, T., Inamori, K., Kawanishi, T., Takeda, H. (2022) Reemployment of Kupffer's vesicle cells into axial and paraxial mesoderm via transdifferentiation. Development, growth & differentiation. 64(3):163-177
- Ye, Z., Kimelman, D. (2020) hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development. Development (Cambridge, England). 147(22):
- Dasgupta, S., Cheng, V., Vliet, S.M.F., Mitchell, C.A., Volz, D.C. (2018) Tris(1,3-dichloro-2-propyl) phosphate Exposure During Early-Blastula Alters the Normal Trajectory of Zebrafish Embryogenesis. Environmental science & technology. 52(18):10820-10828
- Row, R.H., Pegg, A., Kinney, B., Farr, G.H., Maves, L., Lowell, S., Wilson, V., Martin, B.L. (2018) BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity. eLIFE. 7
- Goto, H., Kimmey, S.C., Row, R.H., Matus, D.Q., Martin, B.L. (2017) FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step EMT. Development (Cambridge, England). 144(8):1412-1424
- Gross-Thebing, T., Yigit, S., Pfeiffer, J., Reichman-Fried, M., Bandemer, J., Ruckert, C., Rathmer, C., Goudarzi, M., Stehling, M., Tarbashevich, K., Seggewiss, J., Raz, E. (2017) The Vertebrate Protein Dead End Maintains Primordial Germ Cell Fate by Inhibiting Somatic Differentiation. Developmental Cell. 43:704-715.e5
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