Gene
arr3b
- ID
- ZDB-GENE-030616-74
- Name
- arrestin 3b, retinal (X-arrestin)
- Symbol
- arr3b Nomenclature History
- Previous Names
-
- arr3 (1)
- si:bz46j2.6
- zgc:73331
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in G protein-coupled receptor internalization and visual perception. Predicted to act upstream of or within signal transduction. Is expressed in neural plate; optic primordium; optic vesicle; photoreceptor cell; and visual system. Human ortholog(s) of this gene implicated in myopia. Orthologous to human ARR3 (arrestin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73331 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-arr3b | N/A | (3) |
MO2-arr3b | N/A | Renninger et al., 2011 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Myopia 26, X-linked, female-limited | 301010 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Arrestin | Arrestin, conserved site | Arrestin C-terminal-like domain | Arrestin-like, C-terminal | Arrestin-like, N-terminal | Arrestin, N-terminal | Immunoglobulin E-set |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q6PBM9 | InterPro | 362 | |||||||
UniProtKB:A0AB32T483 | InterPro | 364 | |||||||
UniProtKB:A0AB32T7V0 | InterPro | 366 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-285J6 | ZFIN Curated Data | |
Contained in | BAC | RP71-46J2 | ZFIN Curated Data | |
Encodes | cDNA | MGC:73331 | ZFIN Curated Data | |
Encodes | cDNA | MGC:173982 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_200792 (1) | 1721 nt | ||
Genomic | GenBank:BX088596 | 142350 nt | ||
Polypeptide | UniProtKB:A0AB32T7V0 (1) | 366 aa |
- Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024) Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121
- Lu, Y., Tang, D., Zheng, Z., Wang, X., Zuo, N., Yan, R., Wu, C., Ma, J., Wang, C., Xu, H., He, Y., Liu, D., Liu, S. (2022) Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Frontiers in molecular neuroscience. 15:844668
- Ogawa, Y., Shiraki, T., Fukada, Y., Kojima, D. (2021) Foxq2 determines blue cone identity in zebrafish. Science advances. 7:eabi9784
- Zang, J., Gesemann, M., Keim, J., Samardzija, M., Grimm, C., Neuhauss, S.C. (2021) Circadian regulation of vertebrate cone photoreceptor function. eLIFE. 10:
- Ahrens, N., Elbers, D., Greb, H., Janssen-Bienhold, U., Koch, K.W. (2020) Interaction of G protein-coupled receptor kinases and recoverin isoforms is determined by localization in zebrafish photoreceptors. Biochimica et biophysica acta. Molecular cell research. 1868(4):118946
- Magnuson, J., Bautista, N., Lucero, J., Lund, A., Xu, E.G., Schlenk, D., Burggren, W., Roberts, A.P. (2020) Exposure to crude oil induces retinal apoptosis and impairs visual function in fish. Environmental science & technology. 54(5):2843-2850
- Volkov, L.I., Kim-Han, J.S., Saunders, L.M., Poria, D., Hughes, A.E.O., Kefalov, V.J., Parichy, D.M., Corbo, J.C. (2020) Thyroid hormone receptors mediate two distinct mechanisms of long-wavelength vision. Proceedings of the National Academy of Sciences of the United States of America. 117(26):15262-15269
- Ogawa, Y., Shiraki, T., Asano, Y., Muto, A., Kawakami, K., Suzuki, Y., Kojima, D., Fukada, Y. (2019) Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 116(10):4651-4660
- Schredelseker, T., Driever, W. (2018) Bsx controls pineal complex development. Development (Cambridge, England). 145(13):
- Ogawa, Y., Shiraki, T., Kojima, D., Fukada, Y. (2015) Homeobox transcription factor Six7 governs expression of green opsin genes in zebrafish. Proceedings. Biological sciences. 282(1812):20150659
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