FIGURE

Figure 5

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ZDB-FIG-250513-74
Publication
Martínez-López et al., 2025 - SAMHD1 deficiency enhances macrophage-mediated clearance of Salmonella Typhimurium via NF-κB activation in zebrafish
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Figure 5

Genetic inhibition of nuclear factor kappa B (NF-κB) in macrophages abolishes the hyperresistance of Samhd1-deficient zebrafish larvae to infection with Salmonella enterica serovar Typhimurium. (A) The zebrafish line expressing a dominant negative (DN) form of Nfkbiaa, Tg(UAS:dn-nfkbiaa), was outcrossed with the transgenic line Tg(mpeg1:gal4), and one-cell-stage embryos were injected with gRNA (samhd1 or STD)/Casp9 complexes and infected with STM as previously described. The average from two independent experiments with >80 larvae per group is shown. P-values were calculated using a long-range test. ns, not significant. ***p ≤ 0.001. (B) Model showing the restriction of NF-κB activation by Samhd1 in wild-type macrophages and the hyperresistance of Samhd-1deficient macrophages to STM infection through the induction of NF-κB activation.

Expression Data

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Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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