FIGURE

Figure 1

ID
ZDB-FIG-250513-70
Publication
Martínez-López et al., 2025 - SAMHD1 deficiency enhances macrophage-mediated clearance of Salmonella Typhimurium via NF-κB activation in zebrafish
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Figure 1

Interferon (IFN) stimulation is required to trigger interferon-stimulated gene (ISG) upregulation in Samhd1-deficient zebrafish larvae. (A) Diagram indicating the protein domains. (B) Transcript levels of samhd1 by reverse transcription PCR (RT-PCR) in the head and tail of zebrafish larvae. The average from three independent experiments, each with 25 pooled heads or tails, is shown. (C) Transcript levels of isg15 by reverse transcription quantitative PCR (RT-qPCR) in the head of zebrafish larvae injected with gRNA (samhd1 or STD)/Cas9 complexes with or without 1 pg/egg of pcDNA-IFNphi3. Bars show the mean ± SEM of three independent experiments, each with 25 pooled heads. Data are represented as fold change from control (STD). P-values were calculated using Student’s t-test in (B) and using one-way ANOVA and Tukey’s multiple range test in (C). ns, not significant. *p ≤ 0.05.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Immunol