FIGURE

Fig. 6

ID

ZDB-FIG-250408-15

Publication

Lv et al., 2025 - Angiogenic factor AGGF1 is a general splicing factor regulating angiogenesis and vascular development by alternative splicing of SRSF6

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Fig. 6

AGGF1 regulates endothelial cell proliferation by modulating SRSF6 alternative splicing. (A) Full-length SRSF6-FL protein and short SRSF6-S protein show distinctly different structures as predicted by AlphaFold in UniProt (https://www.uniprot.org/). (B) Cell proliferation analysis using EdU staining for EA.hy926 cells transfected with different siRNA (KD) or mammalian expression plasmid DNA (OE) or combination (n = 3 experiments). (C) Statistical plot of EdU cell proliferation ( n = 9-12 images from three experiments). **p < .01, ****p < .0001 versus control; ns, no significance. (D) Cell proliferation analysis using CCK8 kit for EA.hy926 cells transfected with different siRNA (KD) or mammalian expression plasmid DNA (OE) or combination (n = 3 experiments). *p < .05 versus control; ns, no significance.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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