FIGURE

Fig. 5

ID

ZDB-FIG-241202-10

Publication

García-Pupo et al., 2024 - Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ₁ chaperone protein

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Fig. 5

Amylovis-201 anti-aggregating properties in vitro. Molecular docking with Aβ25–35 peptide. Molecular rigid docking models of the complexes (stick representations): (a) Amylovis-201-Aβ25–35 peptide; (b) NE-100-Aβ25–35 peptide; (c) PRE-084-Aβ25–35 peptide. The Aβ25–35 amyloid peptide code used 1QXC (PDB). (d) Light scattering of Aβ25–35 (25 μmol/L in 40 mmol/L HEPES, pH 7.4) spectrophotometrically monitored at 43 °C in absence or presence of Amylovis-201. Numbers in parentheses indicate molar ratios of proteins. (e) Light scattering of Aβ25–35 in absence or presence of PRE-084 or NE-100. (f) Light scattering of Aβ25–35 when Amylovis-201, PRE-084 or NE-100 were added after 1 h at a stoichiometry 1:1. (g) Same experiment with a stoichiometry1:2. Experiments were performed in triplicates.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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