FIGURE

Figure 6

ID

ZDB-FIG-241122-19

Publication

Carroll et al., 2024 - Genetic requirement of dact1/2 to regulate noncanonical Wnt signaling and calpain 8 during embryonic convergent extension and craniofacial morphogenesis

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Figure 6

Single-cell RNAseq of 4 ss wildtype, dact1/2−/− mutant, and gpc4−/− mutants. (A) Summary schematic showing similar phenotypes in dact1/2−/− and gpc4−/− mutants at 12 hpf and divergent phenotypes at 4 dpf. Single-cell RNAseq was performed during axis extension to compare and contrast dact1/2−/− and gpc4−/− transcriptional programs. Uniform manifold approximation and projection (UMAP) showing cluster identification. (B) UMAP of cell clusters identified by single-cell RNAseq. (C) Dot plot showing the most differentially expressed genes between clusters. (D) UMAP showing dact1, dact2, and gpc4 expression in wildtype embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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