FIGURE

FIGURE 3

ID

ZDB-FIG-241017-106

Publication

Lee et al., 2024 - Transgenic zebrafish as a model for investigating diabetic peripheral neuropathy: investigation of the role of insulin signaling

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FIGURE 3

Depletion of insulin production results in defective rheotaxis behavior, but not locomotor behavior, in ins:epNTR-mCherry zebrafish. (A) Quantification of the distribution of the Ins:epNTR-mCherry larvae performing rheotactic angles following treatment with DMSO and MTZ, and siblings treated with MTZ at 9 dpf, ***p = 0.0004, Chi-squared test (n = 15 larvae per group). (B) Quantification of the percentage of the transgenic larvae showing rheotactic behavior following treatment with DMSO and MTZ, and siblings with MTZ at 9 dpf, **p = 0.0064, Chi-squared test (n = 15 larvae per group). (C) Tracking visualization of the transgenic larvae performing free locomotion in light state at 9 dpf. (D,E) Quantification of the distance moved (mm) (D) and velocity (mm/s) (E) from the transgenic larvae performing free locomotion under light conditions following treatment with DMSO and MTZ, and sibling with MTZ at 9 dpf (n = 32 larvae per group).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.