FIGURE

Fig. 6

ID

ZDB-FIG-231221-48

Publication

Toms et al., 2023 - Successful large gene augmentation of USH2A with non-viral episomal vectors

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Fig. 6

Partial rescue of the Usher 2 protein complex in pS/MAR-USH2A-injected ush2au507 zebrafish Retinal sections from zebrafish at 6 dpf were immunostained with antibodies for two Usher 2 complex proteins: adgrv1 (A–C) and whirlin-a (D–F). Specific punctate expression of adgrv1 (red, A) and whirlin-a (red, D) was detected in the WT photoreceptors, while both proteins were mislocalized in the ush2au507 retina (B and E). In ush2au507 zebrafish injected with pS/MAR-CMV-USH2A at the one-cell stage, specific adgrv1 and whirlin-a expression could be observed in some photoreceptors (C and F). Scale bar, 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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