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Figure 2

ID

ZDB-FIG-231027-16

Publication

Kim et al., 2023 - PPARα activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish

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Figure 2

PPARα activation reduces YAP signaling in Tg(fabp10a:pt-β-catenin) livers. (A) Heatmap showing the differentially expressed hepatocyte, BEC, and YAP-related genes between DMSO- and GW7647-treated groups. Each column represents an independent sample (n = 3). (B) Upstream analysis showing the top 10 significantly upregulated gene sets of transcriptional regulators in the GW7647-treated group. (C) Pathway analysis showing biological pathways significantly induced in the GW7647-treated group. (D) Immunofluorescence images showing the expression of hCCN2:GFP and Anxa4 in control and Tg(fabp10a:pt-β-catenin) livers at 14 dpf. Dashed lines outline the livers. (E) qRT-PCR data showing the relative expression levels of two YAP target genes (ccn1, ccn2) and yap1 between DMSO- and GW7647-treated Tg(fabp10a:pt-β-catenin) livers at 14 dpf. **P < 0.01; statistical significance was calculated using an unpaired two-tailed t-test. (F) Immunohistochemistry data showing Yap1 expression in 14-dpf Tg(fabp10a:pt-β-catenin) livers treated with GW7647. Scale bars, 50 μm.

Expression Data

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Phenotype Data

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Acknowledgments

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