FIGURE

Fig. 3

ID

ZDB-FIG-221218-3

Publication

Xia et al., 2022 - Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration

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Fig. 3

a Normalized expression of marker genes on UMAPs (3 samples combined). b Heatmap of 3 marker genes: tcf21, aldh1a2, and hapln1a. Normalized expression values are shown; cells were sorted by cluster membership. Clusters 2 and 5 are highlighted in red frames. c Images of a 3 dpa heart section showing the ventricular wall with tcf21:nucEGFP in magenta and HCR staining of podxl in green. Nuclei were stained with DAPI (blue). A single-channel image of podxl is shown in grayscale on the right. Arrows indicate representative EGFP⁺podxl⁺ cells. Scale bar, 50 μm. d Images of a 3 dpa heart section showing the ventricular wall with tcf21:nucEGFP in magenta and HCR staining of hapln1a in green. Nuclei were stained with DAPI (blue). A single-channel image of hapln1a is shown in grayscale on the right. Arrows indicate representative EGFP⁺hapln1a⁺ cells. Scale bar, 50 μm. e Normalized expression levels of marker genes for the 3 dpa-specific cluster on UMAPs (3 samples combined).

Expression Data

Genes:	aldh1a2 hapln1a nrg1 pdgfra podxl tcf21 (all 6)
Fish:	pd41Tg/pd41Tg
Condition:	resection: cardiac ventricle
Anatomical Terms:	cardiac mesenchymal cell cardiac ventricle cardiac ventricle epithelium
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pd41Tg/pd41Tg
Condition:	resection: cardiac ventricle
Observed In:	cardiac mesenchymal cell cardiac ventricle cardiac ventricle epithelium
Stage:	Adult

Phenotype Detail

Acknowledgments

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