Gene
aldh1a2
- ID
- ZDB-GENE-011010-3
- Name
- aldehyde dehydrogenase 1 family, member A2
- Symbol
- aldh1a2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable aldehyde dehydrogenase (NAD+) activity. Acts upstream of or within several processes, including chordate embryonic development; myelination; and tube morphogenesis. Is expressed in several structures, including head; heart; immature eye; mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 137 figures from 105 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 40 figures from 24 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| i26 | Allele with one point mutation | Unknown | Missense | ENU | |
| ihb812 | Allele with one deletion | Exon 9 | Unknown | CRISPR | |
| nju26Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| nju27Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| nz15 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa2367 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16776 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| tpl137 | Allele with one deletion | Exon 8 | Exon Loss of Exon 8 | CRISPR | |
| tpl138 | Allele with one deletion | Exon 8 | Exon Loss of Exon 8 | CRISPR | |
| tpl139Tg | Transgenic insertion | Intron 7 | Unknown | DNA and CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diaphragmatic hernia 4, with cardiovascular defects | 620025 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016160 | Aldehyde dehydrogenase, cysteine active site |
| Conserved_site | IPR029510 | Aldehyde dehydrogenase, glutamic acid active site |
| Domain | IPR015590 | Aldehyde dehydrogenase domain |
| Homologous_superfamily | IPR016161 | Aldehyde/histidinol dehydrogenase |
| Homologous_superfamily | IPR016162 | Aldehyde dehydrogenase, N-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aldehyde dehydrogenase, C-terminal | Aldehyde dehydrogenase, cysteine active site | Aldehyde dehydrogenase domain | Aldehyde dehydrogenase, glutamic acid active site | Aldehyde dehydrogenase, N-terminal | Aldehyde/histidinol dehydrogenase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q90XS8 | InterPro | 518 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aldh1a2-201
(1)
|
Ensembl | 3,252 nt | ||
| ncRNA |
aldh1a2-002
(1)
|
Ensembl | 699 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-aldh1a2 | polyclonal | IgG | Rabbit |
|
GeneTex
|
24 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1BAC(aldh1a2:aldh1a2-GFP) |
|
|
| 1 | (6) |
| TgBAC(2aldh1a2:aldh1a2-GFP) |
|
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-94N14 | ZFIN Curated Data | |
| Contains | SNP | rs3727470 | ZFIN Curated Data | |
| Encodes | EST | fb50h01 | ||
| Encodes | cDNA | MGC:195324 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131850 (1) | 2244 nt | ||
| Genomic | GenBank:CR392043 (2) | 112955 nt | ||
| Polypeptide | UniProtKB:Q90XS8 (1) | 518 aa |
- Ye, J., Lu, L., Rui, X.H., Ren, M.D., Tu, F., Shang, Z.B., Liu, J. (2025) Zebrafish as a model for investigating Klebsiella pneumoniae-driven lung injury and therapeutic targets. Experimental Lung Research. 51:112211-22
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Chen, B., Ran, Q., Chen, X., Deng, Z., Zhou, R., Zhang, Y., Liu, M., Li, B., Huang, S., Wang, P., Huang, S. (2024) Cxcr4a regulates heart progenitor development and cardiac rhythm in zebrafish. Biochemistry and biophysics reports. 39:101782101782
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Dong, Y., Yang, Y., Wang, H., Feng, D., Nist, E., Yapundich, N., Spurlock, B., Craft, M., Qian, L., Liu, J. (2024) Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells. Science advances. 10:eadk4694
- Jiang, X., Zhao, K., Sun, Y., Song, X., Yi, C., Xiong, T., Wang, S., Yu, Y., Chen, X., Liu, R., Yan, X., Antos, C.L. (2024) The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b. PLoS Biology. 22:e3002565e3002565
- Liu, T., He, W., Zhong, Z., Lu, C., Wu, L., Wang, Z., Smith, W.K., Shi, Q., Long, Q., Wang, H. (2024) The circadian clock orchestrates spermatogonial differentiation and fertilization by regulating retinoic acid signaling in vertebrates. National science review. 12:nwae456nwae456
- Lu, Y., Travnickova, J., Badonyi, M., Rambow, F., Coates, A., Khan, Z., Marques, J., Murphy, L.C., Garcia-Martinez, P., Marais, R., Louphrasitthiphol, P., Chan, A.H.Y., Schofield, C.J., von Kriegsheim, A., Marsh, J.A., Pavet, V., Sansom, O.J., Illingworth, R.S., Patton, E.E. (2024) ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Cell Reports. 43:114406114406
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Zeng, T., Lv, J., Liang, J., Xie, B., Liu, L., Tan, Y., Zhu, J., Jiang, J., Xie, H. (2024) Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway. Frontiers in cell and developmental biology. 12:13813621381362
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