FIGURE

Fig. 4

ID

ZDB-FIG-210603-4

Publication

Doll et al., 2020 - A zebrafish model for HAX1-associated congenital neutropenia

Other Figures

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Fig. 4

Normal development of erythrocytes, macrophages and hematopoietic stem cells in the hax1 morphants. (A-H) Left panels show representative images of whole mount in situ hybridization for gata1 (A), hbae1.1 (B), pu.1 (C), l-plastin (D), lyz (E), g-csfr (F), mpeg1.1 (G) and cmyb (H) expression in uninjected (WT) and hax1 e1-MO injected embryos at 24 hours post-fertilization (hpf) (A,B) or 48 hpf (C-H). Right panels show quantitative numbers of stained cells in the trunk region. Scale bars indicate 100 mm. Each dot in C-G represents an individual embryo. Data are means } standard deviation.

Expression Data

Genes:	csf3r lcp1 lyz
Fish:	TU + MO1-hax1
Knockdown Reagent:	MO1-hax1
Anatomical Terms:	neutrophil trunk monocyte trunk myeloid leukocyte
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU + MO1-hax1 TU + MO2-hax1
Knockdown Reagents:	MO1-hax1 MO2-hax1
Observed In:	definitive hemopoiesis erythrocyte differentiation leukocyte macrophage differentiation neutrophil trunk monocyte trunk myeloid leukocyte (all 7)
Stage Range:	Prim-5 to Long-pec

Phenotype Detail

Acknowledgments

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