Gene

lcp1

ID
ZDB-GENE-991213-5
Name
lymphocyte cytosolic protein 1 (L-plastin)
Symbol
lcp1 Nomenclature History
Previous Names
  • cb245 (1)
  • fj24b12
  • l plastin
  • L-plastin (1)
  • leucocyte-specific plastin
  • wu:fj24b12
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly and actin filament network formation. Located in cytoplasm. Is expressed in several structures, including eye; hematopoietic cell; hematopoietic system; mesoderm; and renal system. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human LCP1 (lymphocyte cytosolic protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
233 figures from 176 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Kell et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa45867Allele with one point mutationUnknownPremature StopENU
ud1Allele with one delinsExon 2Frameshift, Premature StopCRISPR
ud2Allele with one delinsExon 2Frameshift, Premature StopCRISPR
ud3Allele with one deletionExon 2Frameshift, Premature StopCRISPR
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-lcp1 (4)
CRISPR2-lcp1
    Baumgartner et al., 2019
    1 - 2 of 2
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    Human Disease
    Associated With lcp1 Human Ortholog
    No data available
    Associated With lcp1 Via Experimental Models
    No data available
    Gene Ontology
    Protein Domains
    Domain, Family, and Site Summary
    Type InterPro ID Name
    Binding_site IPR018247 EF-Hand 1, calcium-binding site
    Conserved_site IPR001589 Actinin-type actin-binding domain, conserved site
    Domain IPR001715 Calponin homology domain
    Domain IPR002048 EF-hand domain
    Family IPR039959 Fimbrin/Plastin
    1 - 5 of 7 Show all
    Domain Details Per Protein
    Protein Additional Resources Length Actinin-type actin-binding domain, conserved site Calponin homology domain CH domain superfamily EF-Hand 1, calcium-binding site EF-hand domain EF-hand domain pair Fimbrin/Plastin
    UniProtKB:A0A140LGK1 InterPro 624
    UniProtKB:Q6P698 InterPro 624
    1 - 2 of 2
    Transcripts
    Genome Browsers
    Type Name Annotation Method Has Havana Data Length (nt) Analysis
    mRNA lcp1-201 (1) Ensembl 2,283 nt
    1 - 1 of 1
    Interactions and Pathways
    No data available
    Antibodies
    Name Type Antigen Genes Isotype Host Organism Assay Source Citations
    Ab3-lcp1 polyclonal Rabbit
    • IHC
    19
    Ab5-lcp1 polyclonal IgG Rabbit
    • IHC
    GeneTex
    22
    Ab2-lcp1 polyclonal Rabbit
    • IHC
    • WB
    55
    Ab1-lcp1 polyclonal Rabbit
    • IHC
    20
    1 - 4 of 4
    Plasmids
    No data available
    Constructs
    Construct Regulatory Region Coding Sequence Species Tg Lines Citations
    Tg(lcp1:Cre-P2A-EGFP-CAAX)
    • lcp1
    • Danio rerio
    1 (2)
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    Marker Relationships
    Relationship Marker Type Marker Accession Numbers Citations
    Contained inFosmidZFOS-1926B4ZFIN Curated Data
    EncodesESTcb245Thisse et al., 2001
    EncodesESTfj24b12
    EncodescDNAMGC:66040ZFIN Curated Data
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Citations