Gene
lcp1
- ID
- ZDB-GENE-991213-5
- Name
- lymphocyte cytosolic protein 1 (L-plastin)
- Symbol
- lcp1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly and actin filament network formation. Located in cytoplasm. Is expressed in several structures, including eye; hematopoietic cell; hematopoietic system; mesoderm; and renal system. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human LCP1 (lymphocyte cytosolic protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 233 figures from 176 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb245 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Kell et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa45867 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ud1 | Allele with one delins | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| ud2 | Allele with one delins | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| ud3 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | CRISPR |
1 - 4 of 4
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lcp1 | (4) | |
| CRISPR2-lcp1 | Baumgartner et al., 2019 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Actinin-type actin-binding domain, conserved site | Calponin homology domain | CH domain superfamily | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Fimbrin/Plastin |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A140LGK1 | InterPro | 624 | |||||||
| UniProtKB:Q6P698 | InterPro | 624 |
1 - 2 of 2
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-1926B4 | ZFIN Curated Data | |
| Encodes | EST | cb245 | Thisse et al., 2001 | |
| Encodes | EST | fj24b12 | ||
| Encodes | cDNA | MGC:66040 | ZFIN Curated Data |
1 - 4 of 4
Show