FIGURE

Fig. 5

ID

ZDB-FIG-140211-6

Publication

Breau et al., 2013 - A Hox gene controls lateral line cell migration by regulating chemokine receptor expression downstream of Wnt signaling

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Fig. 5

Hoxb8a is a target of Wnt signaling and is sufficient to down-regulate cxcr7b upon inhibition of Wnt pathway. ISH showing expression of (A and B) lef1, (C and D) hoxb8a, (E and F) hoxb6a, (G and H) cxcr4b, and (I and J) cxcr7b in hsp70:dkk1gfp embryos and control heat-shocked siblings. Embryos were heat-shocked at 24 hpf and fixed at 30 hpf. ISH to detect expression of (K) cxcr4b and (M) cxcr7b followed by Myc immunostaining (brown) in hsp70:dkk1gfp/cldnb4.2:gal4 x UAS:Hoxb8aMT embryos. ISH to detect expression of (L) cxcr4b and (N) cxcr7b in hsp70:dkk1gfp/cldnb4.2:gal4 x UAS:Hoxb8aVP16 embryos. The number of embryos indicated are pooled from three independent experiments and they are as follows: A, 57; B, 60; C, 62; D, 58; E, 41; F, 63; G, 66; H, 40; I, 67; J, 67; K, 23; L, 55; M, 38; N, 46. (Scale bar: 25 µm.)

Expression Data

Genes:	ackr3b cxcr4b hoxb6a hoxb8a lef1
Fish:	WT w32Tg nim11Tg; nim12Tg; w32Tg nim11Tg; nim14Tg; w32Tg
Condition:	heat shock
Anatomical Terms:	posterior lateral line primordium posterior lateral line primordium posterior-most region
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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