Gene
hoxb8a
- ID
- ZDB-GENE-990415-108
- Name
- homeobox B8a
- Symbol
- hoxb8a Nomenclature History
- Previous Names
-
- gp-8
- hoxb8
- fj67g02
- wu:fj67g02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell population proliferation and posterior lateral line neuromast primordium migration. Predicted to be active in nucleus. Is expressed in several structures, including nervous system; neural tube; pancreatic system; paraxial mesoderm; and pronephros. Orthologous to human HOXB8 (homeobox B8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64159 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Breau et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa14443 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-hoxb8a | N/A | (2) |
MO2-hoxb8a | N/A | Breau et al., 2013 |
MO3-hoxb8a | N/A | Sundaramoorthi et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Antp homeobox transcription factor | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein, antennapedia type, conserved site | Homeodomain | Homeodomain, metazoa |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q8AWZ0 | InterPro | 245 | |||||||
UniProtKB:A0A8M2BJC8 | InterPro | 246 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
hoxb8a-201
(1)
|
Ensembl | 1,817 nt | ||
mRNA | ottdart00000001809 (1) | Havana | 1,752 nt |
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Interactions and Pathways
No data available
Plasmids
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-72A16 | ZFIN Curated Data | |
Contained in | PAC | BUSM1-254O17 | ZFIN Curated Data | |
Encodes | EST | fj67g02 | ||
Encodes | cDNA | MGC:64159 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131120 (1) | 1821 nt | ||
Genomic | GenBank:AL645782 (1) | 119385 nt | ||
Polypeptide | UniProtKB:A0A8M2BJC8 (1) | 246 aa |
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Wang, H., He, J., Han, X., Wu, X., Ye, X., Lv, W., Zu, Y. (2023) hoxa1a-Null Zebrafish as a Model for Studying HOXA1-Associated Heart Malformation in Bosley-Salih-Alorainy Syndrome. Biology. 12(7):
- Weiss, J.M., Hunter, M.V., Cruz, N.M., Baggiolini, A., Tagore, M., Ma, Y., Misale, S., Marasco, M., Simon-Vermot, T., Campbell, N.R., Newell, F., Wilmott, J.S., Johansson, P.A., Thompson, J.F., Long, G.V., Pearson, J.V., Mann, G.J., Scolyer, R.A., Waddell, N., Montal, E.D., Huang, T.H., Jonsson, P., Donoghue, M.T.A., Harris, C.C., Taylor, B.S., Xu, T., Chaligné, R., Shliaha, P.V., Hendrickson, R., Jungbluth, A.A., Lezcano, C., Koche, R., Studer, L., Ariyan, C.E., Solit, D.B., Wolchok, J.D., Merghoub, T., Rosen, N., Hayward, N.K., White, R.M. (2022) Anatomic position determines oncogenic specificity in melanoma. Nature. 604(7905):354-361
- Mukaigasa, K., Sakuma, C., Yaginuma, H. (2021) The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements. Development, growth & differentiation. 63(7):372-391
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
- Lan, Y., Pan, H., Li, C., Banks, K.M., Sam, J., Ding, B., Elemento, O., Goll, M.G., Evans, T. (2019) TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis. Cell Reports. 26:720-732.e4
- Lu, C.J., Fan, X.Y., Guo, Y.F., Cheng, Z.C., Dong, J., Chen, J.Z., Li, L.Y., Wang, M.W., Wu, Z.K., Wang, F., Tong, X.J., Luo, L.F., Tang, F.C., Zhu, Z.Y., Zhang, B. (2018) Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development. Journal of molecular cell biology. 11(6):435-447
- Malmstrøm, M., Britz, R., Matschiner, M., Tørresen, O.K., Hadiaty, R.K., Yaakob, N., Tan, H.H., Jakobsen, K.S., Salzburger, W., Rüber, L. (2018) The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and Miniaturized Genomes. Genome biology and evolution. 10:1088-1103
- Chang, J., Skromne, I., Ho, R.K. (2016) CDX4 and retinoic acid interact to position the hindbrain-spinal cord transition. Developmental Biology. 410(2):178-89
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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