PUBLICATION

Mutations affecting development of the zebrafish retina

Authors
Malicki, J., Neuhauss, S.C., Schier, A.F., Solnica-Krezel, L., Stemple, D.L., Stainier, D.Y., Abdelilah, S., Zwartkruis, F., Rangini, Z., and Driever, W.
ID
ZDB-PUB-970210-22
Date
1996
Source
Development (Cambridge, England)   123: 263-273 (Journal)
Registered Authors
Abdelilah-Seyfried, Salim, Driever, Wolfgang, Malicki, Jarema, Neuhauss, Stephan, Schier, Alexander, Solnica-Krezel, Lilianna, Stainier, Didier, Stemple, Derek L.
Keywords
retina; neurogenesis; zebrafish
MeSH Terms
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Body Patterning/genetics
  • Animals
  • Pigmentation/genetics
  • Eye Abnormalities/genetics
  • Retinal Degeneration/genetics
  • Embryonic Development
  • Nerve Degeneration/genetics
  • Neurons/pathology
  • Phenotype
  • Retina/abnormalities
  • Retina/embryology*
  • Eye/embryology
  • Eye/growth & development
  • Mutagenesis*
(all 16)
PubMed
9007246 Full text @ Development
Abstract
In a large scale screen for genetic defects in zebrafish embryogenesis we identified 49 mutations affecting development of the retina. Based on analysis of living embryos as well as histological sections, we grouped the isolated mutations into six phenotypic categories. (1) Mutations in three loci result in a loss of wild-type laminar pattern of the neural retina. (2) Defects in four loci lead to an abnormal specification of the eye anlagen. Only one eye frequently forms in this class of mutants. (3) Seven loci predominantly affect development of the outer retinal layers. Mutants in this category display cell loss mainly in the photoreceptor cell layer. (4) Nine mutations cause retardation of eye growth without any other obvious abnormalities in the retina. (5) A group of twelve mutations is characterized by nonspecific retinal degeneration. (6) Four mutations display retinal degeneration associated with a pigmentation defect. Finally, two mutations, one with absence of the ventral retina and one with an eye-specific pigmentation defect, are not classified in any of the above groups. The identified mutations affect numerous aspects of eye development, including: specification of the eye anlage, growth rate of the optic cup, establishment of retinal stratification, specification or differentiation of retinal neurons and formation of the dorsoventral axis in the developing eye.
Genes / Markers
Figures
Figure Gallery (6 images)
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Expression
No data available
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
b16
    Deficiency
    m98
      Point Mutation
      m101
        Unknown
        m117
          Point Mutation
          m122
            Unknown
            m124
              Unknown
              m125
                Unknown
                m129
                  Point Mutation
                  m134
                    Point Mutation
                    m148
                      Unknown
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                      Human Disease / Model
                      No data available
                      Sequence Targeting Reagents
                      No data available
                      Fish
                      Antibodies
                      No data available
                      Orthology
                      No data available
                      Engineered Foreign Genes
                      No data available
                      Mapping
                      No data available