Gene

tdgf1

ID
ZDB-GENE-990415-198
Name
teratocarcinoma-derived growth factor 1
Symbol
tdgf1 Nomenclature History
Previous Names
  • cb85 (1)
  • cripto
  • oep
  • one eyed pinhead
  • one-eyed pinhead
  • wu:fe01d04
  • zgc:109829
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable activin receptor binding activity and nodal binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regionalization. Located in external side of plasma membrane. Is expressed in several structures, including EVL; cardiovascular system; diencephalon; ectoderm; and mesoderm. Used to study neural tube defect. Human ortholog(s) of this gene implicated in colon cancer and congenital heart disease. Orthologous to human CRIPTO (cripto, EGF-CFC family member).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
30 figures from 21 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
66 figures from 44 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ko202Allele with one point mutationExon 3Premature StopCRISPR
la017432TgTransgenic insertionUnknownUnknownDNA
m134Allele with one point mutationUnknownPremature StopENU
tdgf1_unspecifiedUnspecified AlleleUnknownUnknownnot specified
tz257Allele with one point mutationStart CodonStart LossENU
1 - 5 of 5
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Sequence Targeting Reagents
Human Disease
Associated With tdgf1 Human Ortholog
No data available
Associated With tdgf1 Via Experimental Models
Human Disease Fish Conditions Citations
neural tube defect tdgf1m134/m134 standard conditions Ma et al., 2015
1 - 1 of 1
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR019011 Cryptic/Cripto, CFC domain
1 - 2 of 2
Domain Details Per Protein
Protein Additional Resources Length Cryptic/Cripto, CFC domain EGF-like domain
UniProtKB:F1Q691 InterPro 190
UniProtKB:A7MCB2 InterPro 183
1 - 2 of 2
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tdgf1-201 (1) Ensembl 573 nt
mRNA tdgf1-202 (1) Ensembl 1,769 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations