ZFIN Morpholino: MO3-bmp4

Target Location

Genome Build: GRCz11Chromosome: 17

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-bmp4

No data available

Phenotype

Phenotype resulting from MO3-bmp4

Phenotype	Fish	Figures
atrium position, abnormal	WT + MO3-bmp4	Fig. 6 from Chocron et al., 2007
axial chorda mesoderm decreased size, abnormal	WT + MO3-bmp4	Fig. 2 from Esterberg et al., 2008
cell population proliferation disrupted, abnormal	WT + MO3-bmp4	Fig. 4 from Esterberg et al., 2008
chordo neural hinge decreased size, abnormal	WT + MO3-bmp4	Fig. 3 from Esterberg et al., 2008
determination of left/right symmetry process quality, abnormal	WT + MO3-bmp4	Fig. 6 from Chocron et al., 2007

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Phenotype of all Fish created by or utilizing MO3-bmp4

Phenotype	Fish	Conditions	Figures
caudal fin decreased size, abnormal	WT + MO1-bmp4 + MO3-bmp4	standard conditions	Fig. S2 from Smith et al., 2008
whole organism wholly dorsalized, abnormal	WT + MO3-bmp4	standard conditions	Fig. 5 from Chocron et al., 2007
liver duplicated, abnormal	WT + MO3-bmp4	standard conditions	Fig. 6 from Chocron et al., 2007
gut decreased curvature, abnormal	WT + MO3-bmp4	standard conditions	Fig. 6 from Chocron et al., 2007
notochord development disrupted, abnormal	WT + MO3-bmp4	standard conditions	Fig. 3 , Fig. 4 from Esterberg et al., 2008

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Citations

Include unpublished citations

Rago, L., Castroviejo, N., Fazilaty, H., Garcia-Asencio, F., Ocaña, O.H., Galcerán, J., Nieto, M.A. (2019) MicroRNAs Establish the Right-Handed Dominance of the Heart Laterality Pathway in Vertebrates. Developmental Cell. 51:446-459.e5
Grassini, D.R., Lagendijk, A.K., De Angelis, J.E., Da Silva, J., Jeanes, A., Zettler, N., Bower, N.I., Hogan, B.M., Smith, K.A. (2018) Nppa and Nppb act redundantly during zebrafish cardiac development to confine AVC marker expression and reduce cardiac jelly volume. Development (Cambridge, England). 145(12)
Monteiro, R., Pinheiro, P., Joseph, N., Peterkin, T., Koth, J., Repapi, E., Bonkhofer, F., Kirmizitas, A., Patient, R. (2016) Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Developmental Cell. 38(4):358-70
Gu, W., Monteiro, R., Zuo, J., Simões, F.C., Martella, A., Andrieu-Soler, C., Grosveld, F., Sauka-Spengler, T., Patient, R. (2015) A Novel TGFβ Modulator that Uncouples R-Smad/I-Smad-Mediated Negative Feedback from R-Smad/Ligand-Driven Positive Feedback. PLoS Biology. 13:e1002051
Lenhart, K.F., Holtzman, N.G., Williams, J.R., and Burdine, R.D. (2013) Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left-Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry. PLoS Genetics. 9(1):e1003109
Ramel, M.C., and Hill, C.S. (2013) The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Developmental Biology. 378(2):170-82
Huang, S., Ma, J., Liu, X., Zhang, Y., and Luo, L. (2011) Retinoic acid signaling sequentially controls visceral and heart laterality in Zebrafish. The Journal of biological chemistry. 286(32):28533-43
Smith, K.A., Lagendijk, A.K., Courtney, A.D., Chen, H., Paterson, S., Hogan, B.M., Wicking, C., and Bakkers, J. (2011) Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development. Development (Cambridge, England). 138(19):4193-4198
French, C.R., Erickson, T., French, D.V., Pilgrim, D.B., and Waskiewicz, A.J. (2009) Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development. Developmental Biology. 333(1):37-47
Wilkinson, R.N., Pouget, C., Gering, M., Russell, A.J., Davies, S.G., Kimelman, D., and Patient, R. (2009) Hedgehog and Bmp polarize hematopoietic stem cell emergence in the zebrafish dorsal aorta. Developmental Cell. 16(6):909-916

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