Gene

bmp4

ID
ZDB-GENE-980528-2059
Name
bone morphogenetic protein 4
Symbol
bmp4 Nomenclature History
Previous Names
  • bmp-4
  • zbmp-4
  • etID309887.17 (1)
  • zgc:100779
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable cytokine activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; determination of bilateral symmetry; and embryonic organ development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; fin; head; mesoderm; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and syndromic microphthalmia 6. Orthologous to human BMP4 (bone morphogenetic protein 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
320 figures from 245 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
20 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
b1149Allele with one point mutationUnknownMissenseENU
b1150Allele with one point mutationUnknownPremature StopENU
b1172Allele with one point mutationUnknownPremature StopENU
la010179TgTransgenic insertionUnknownUnknownDNA
la013167TgTransgenic insertionUnknownUnknownDNA
ouc1003Allele with one delinsExon 3UnknownCRISPR
sa36537Allele with one point mutationUnknownPremature StopENU
st37Allele with one insertionUnknownUnknownnot specified
st72Allele with one point mutationExon 4Premature StopENU
umo32Allele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With bmp4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
orofacial cleft 11 Alliance Orofacial cleft 11 600625
syndromic microphthalmia 6 Alliance Microphthalmia, syndromic 6 607932
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Associated With bmp4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Domain IPR047833 Bone morphogenetic protein 4, TGF-beta-like domain
Family IPR015615 Transforming growth factor-beta-related
1 - 5 of 6 Show all
Domain Details Per Protein
Protein Additional Resources Length Bone morphogenetic protein 4, TGF-beta-like domain Cystine-knot cytokine TGF-beta, propeptide Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:O57574 InterPro 400
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA bmp4-201 (1) Ensembl 2,991 nt
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Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(-7.5bmp4:GFP)
  • bmp4
  • Danio rerio
2 (11)
Tg(hsp70l:bmp4,myl7:EGFP)
  • Danio rerio
1 (5)
Tg(hsp70l:GAL4,UAS:bmp4)
  • Danio rerio
1Zuniga et al., 2011
Tg(Ola.Rx2:bmp4,myl7:EGFP)
  • Danio rerio
  • Oryzias latipes
1 (4)
Tg(UAS:bmp4,myl7:EGFP)
  • Danio rerio
1 (8)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-374D11ZFIN Curated Data
Contained inBACCH211-287A24ZFIN Curated Data
EncodesESTeu728Thisse et al., 2005
EncodescDNAMGC:100779ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanBMP414
Conserved genome location (synteny) (1)
Amino acid sequence comparison (7)
Phylogenetic tree (3)
MouseBmp414
Phylogenetic tree (3)
Amino acid sequence comparison (5)
Citations
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