Gene
bmp4
- ID
- ZDB-GENE-980528-2059
- Name
- bone morphogenetic protein 4
- Symbol
- bmp4 Nomenclature History
- Previous Names
-
- bmp-4
- zbmp-4
- etID309887.17 (1)
- zgc:100779
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; determination of bilateral symmetry; and embryonic organ development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; fin; head; mesoderm; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and syndromic microphthalmia 6. Orthologous to human BMP4 (bone morphogenetic protein 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 320 figures from 245 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu728 (27 images)
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
b1149 | Allele with one point mutation | Unknown | Missense | ENU | |
b1150 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
b1172 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
la010179Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la013167Tg | Transgenic insertion | Unknown | Unknown | DNA | |
ouc1003 | Allele with one delins | Exon 3 | Unknown | CRISPR | |
sa36537 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
st37 | Allele with one insertion | Unknown | Unknown | not specified | |
st72 | Allele with one point mutation | Exon 4 | Premature Stop | ENU | |
umo32 | Allele with one deletion | Unknown | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-bmp4 | Zebrafish Nomenclature Committee | |
CRISPR2-bmp4 | Chen et al., 2023 | |
MO1-bmp4 | N/A | (12) |
MO2-bmp4 | N/A | (2) |
MO3-bmp4 | N/A | (13) |
MO4-bmp4 | N/A | Weber et al., 2008 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
orofacial cleft 11 | Alliance | Orofacial cleft 11 | 600625 |
syndromic microphthalmia 6 | Alliance | Microphthalmia, syndromic 6 | 607932 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017948 | Transforming growth factor beta, conserved site |
Domain | IPR001111 | TGF-beta, propeptide |
Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
Domain | IPR047833 | Bone morphogenetic protein 4, TGF-beta-like domain |
Family | IPR015615 | Transforming growth factor-beta-related |
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Domain Details Per Protein
Protein | Additional Resources | Length | Bone morphogenetic protein 4, TGF-beta-like domain | Cystine-knot cytokine | TGF-beta, propeptide | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
---|---|---|---|---|---|---|---|---|
UniProtKB:O57574 | InterPro | 400 |
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Interactions and Pathways
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(-7.5bmp4:GFP) |
|
| 2 | (11) | |
Tg(hsp70l:bmp4,myl7:EGFP) |
|
| 1 | (5) | |
Tg(hsp70l:GAL4,UAS:bmp4) |
|
| 1 | Zuniga et al., 2011 | |
Tg(Ola.Rx2:bmp4,myl7:EGFP) |
|
| 1 | (4) | |
Tg(UAS:bmp4,myl7:EGFP) |
|
| 1 | (8) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-374D11 | ZFIN Curated Data | |
Contained in | BAC | CH211-287A24 | ZFIN Curated Data | |
Encodes | EST | eu728 | Thisse et al., 2005 | |
Encodes | cDNA | MGC:100779 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131342 (1) | 2985 nt | ||
Genomic | GenBank:CR391996 (2) | 66448 nt | ||
Polypeptide | UniProtKB:O57574 (1) | 400 aa |
- Angom, R.S., Joshi, A., Patowary, A., Sivadas, A., Ramasamy, S., K V, S., Kaushik, K., Sabharwal, A., Lalwani, M.K., K, S., Singh, N., Scaria, V., Sivasubbu, S. (2024) Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function. Frontiers in cell and developmental biology. 12:13392921339292
- Chen, B., Ran, Q., Chen, X., Deng, Z., Zhou, R., Zhang, Y., Liu, M., Li, B., Huang, S., Wang, P., Huang, S. (2024) Cxcr4a regulates heart progenitor development and cardiac rhythm in zebrafish. Biochemistry and biophysics reports. 39:101782101782
- Jiang, X., Zhao, K., Sun, Y., Song, X., Yi, C., Xiong, T., Wang, S., Yu, Y., Chen, X., Liu, R., Yan, X., Antos, C.L. (2024) The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b. PLoS Biology. 22:e3002565e3002565
- Lovely, C.B. (2024) Bone Morphogenetic Protein signaling pathway - ethanol interactions disrupt palate formation independent of gata3. Reproductive toxicology (Elmsford, N.Y.). 131:108754
- Portolés, I., Ribera, J., Fernandez-Galán, E., Lecue, E., Casals, G., Melgar-Lesmes, P., Fernández-Varo, G., Boix, L., Sanduzzi, M., Aishwarya, V., Reig, M., Jiménez, W., Morales-Ruiz, M. (2024) Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice. International Journal of Molecular Sciences. 25(7):
- Ren, M., Chen, X., Dai, L., Tu, J., Hu, H., Sun, X., Luo, J., Li, P., Fu, Y., Zhu, Y., Sun, W., Tang, Z., Liu, M., Ren, X., Lu, Q. (2024) Knockout of dhx38 Causes Inner Ear Developmental Defects in Zebrafish. Biomedicines. 13:
- Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., Zhang, G., Sun, Q., Wang, W., Wang, Q., Zhang, W., Chen, D. (2024) The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports. 43:113873113873
- Auman, H.J., Fernandes, I.H., Berríos-Otero, C.A., Colombo, S., Yelon, D. (2023) Zebrafish smarcc1a mutants reveal requirements for BAF chromatin remodeling complexes in distinguishing the atrioventricular canal from the cardiac chambers. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(1):157-172
- Bulk, J., Kyrychenko, V., Rensinghoff, P.M., Ghaderi Ardekani, Z., Heermann, S. (2023) Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction of bmp4, Oversaturating BMP Antagonists in Zebrafish. International Journal of Molecular Sciences. 24(9):
- Chen, L., Zhong, S., Wang, Y., Wang, X., Liu, Z., Hu, G. (2023) Bmp4 in Zebrafish Enhances Antiviral Innate Immunity through p38 MAPK (Mitogen-Activated Protein Kinases) Pathway. International Journal of Molecular Sciences. 24(19):
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