ZFIN Morpholino: MO2-notch1b

Target Location

Genome Build: GRCz11Chromosome: 5

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-notch1b

No data available

Phenotype

Phenotype resulting from MO2-notch1b

Phenotype	Fish	Figures
angiogenic sprout increased amount, abnormal	notch1b^{zf2046/zf2046}; hu4624Tg; nz101Tg + MO2-notch1b	Fig. 8 from Chiang et al., 2017
blood vessel morphogenesis disrupted, abnormal	y1Tg + MO2-notch1b	Fig. 3 from Leslie et al., 2007
cardiac conduction rate, abnormal	WT + MO2-notch1b	Fig. 7 from Milan et al., 2006
dorsal telencephalon radial glial cell cellular potency, abnormal	AB + MO2-notch1b	Fig. 8 from Alunni et al., 2013
dorsal telencephalon ventricular zone has extra parts of type neuron, abnormal	AB + MO2-notch1b	Fig. 8 from Alunni et al., 2013

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Phenotype of all Fish created by or utilizing MO2-notch1b

Phenotype	Fish	Conditions	Figures
dorsal telencephalon radial glial cell cellular potency, abnormal	AB + MO2-notch1b	standard conditions	Fig. 8 from Alunni et al., 2013
dorsal telencephalon ventricular zone has extra parts of type neuron, abnormal	AB + MO2-notch1b	standard conditions	Fig. 8 from Alunni et al., 2013
neuronal stem cell population maintenance decreased occurrence, abnormal	AB + MO2-notch1b	standard conditions	Fig. 8 from Alunni et al., 2013
cardiac conduction rate, abnormal	WT + MO2-notch1b	standard conditions	Fig. 7 from Milan et al., 2006
heart efnb2a expression decreased amount, abnormal	twu26Tg + MO2-notch1b	control	Fig. 4 from Samsa et al., 2015

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Citations

Include unpublished citations

Lin, Y., Yang, Q., Lin, X., Liu, X., Qian, Y., Xu, D., Cao, N., Han, X., Zhu, Y., Hu, W., He, X., Yu, Z., Kong, X., Zhu, L., Zhong, Z., Liu, K., Zhou, B., Wang, Y., Peng, J., Zhu, W., Wang, J. (2023) Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation. Circulation. 149(8):605-626
Ando, K., Wang, W., Peng, D., Chiba, A., Lagendijk, A., Barske, L., Crump, J.G., Stainier, D.Y.R., Lendahl, U., Koltowska, K., Hogan, B.M., Fukuhara, S., Mochizuki, N., Betsholtz, C. (2019) Peri-arterial specification of vascular mural cells from naïve mesenchyme requires Notch signaling. Development (Cambridge, England). 146(2):
Chen, X., Gays, D., Milia, C., Santoro, M.M. (2017) Cilia Control Vascular Mural Cell Recruitment in Vertebrates. Cell Reports. 18:1033-1047
Chiang, I.K., Fritzsche, M., Pichol-Thievend, C., Neal, A., Holmes, K., Lagendijk, A., Overman, J., D'Angelo, D., Omini, A., Hermkens, D., Lesieur, E., Liu, K., Ratnayaka, I., Corada, M., Bou-Gharios, G., Carroll, J., Dejana, E., Schulte-Merker, S., Hogan, B., Beltrame, M., De Val, S., Francois, M. (2017) SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development (Cambridge, England). 144(14):2629-2639
Samsa, L.A., Givens, C., Tzima, E., Stainier, D.Y., Qian, L., Liu, J. (2015) Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish. Development (Cambridge, England). 142:4080-91
Yokota, Y., Nakajima, H., Wakayama, Y., Muto, A., Kawakami, K., Fukuhara, S., Mochizuki, N. (2015) Endothelial Ca(2+) oscillations reflect VEGFR signaling-regulated angiogenic capacity in vivo. eLIFE. 4
Zhou, Y., Ge, R., Wang, R., Liu, F., Huang, Y., Liu, H., Hao, Y., Zhou, Q., Wang, C. (2015) UXT potentiates angiogenesis by attenuating Notch signaling. Development (Cambridge, England). 142(4):774-86
Okigawa, S., Mizoguchi, T., Okano, M., Tanaka, H., Isoda, M., Jiang, Y.J., Suster, M., Higashijima, S.I., Kawakami, K., Itoh, M. (2014) Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination. Developmental Biology. 391(2):196-206
Alunni, A., Krecsmarik, M., Bosco, A., Galant, S., Pan, L., Moens, C.B., and Bally-Cuif, L. (2013) Notch3 signaling gates cell cycle entry and limits neural stem cell amplification in the adult pallium. Development (Cambridge, England). 140(16):3335-47
Da'as, S.I., Coombs, A.J., Balci, T.B., Grondin, C.A., Ferrando, A.A., and Berman, J.N. (2012) The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo. Blood. 119(15):3585-3594

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