PUBLICATION

Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish

Authors
Geudens, I., Herpers, R., Hermans, K., Segura, I., Ruiz de Almodovar, C., Bussmann, J., De Smet, F., Vandevelde, W., Hogan, B.M., Siekmann, A., Claes, F., Moore, J.C., Pistocchi, A.S., Loges, S., Mazzone, M., Mariggi, G., Bruyere, F., Cotelli, F., Kerjaschki, D., Noel, A., Foidart, J.M., Gerhardt, H., Ny, A., Langenberg, T., Lawson, N.D., Duckers, H.J., Schulte-Merker, S., Carmeliet, P., and Dewerchin, M.
ID
ZDB-PUB-101213-1
Date
2010
Source
Arterioscler. Thromb. Vasc. Biol.   30(9): 1695-1702 (Journal)
Registered Authors
Bussmann, Jeroen, Cotelli, Franco, Herpers, Robert, Hogan, Ben M., Langenberg, Tobias, Lawson, Nathan, Moore, John, Schulte-Merker, Stefan, Siekmann, Arndt Friedrich
Keywords
vascular biology, gene silencing, lymphangiogenesis, notch signaling, zebrafish
MeSH Terms
  • Signal Transduction*
  • Lymphangiogenesis*/genetics
  • Biomarkers/metabolism
  • Endothelial Cells/metabolism
  • Membrane Proteins/genetics
  • Membrane Proteins/metabolism*
  • RNA, Messenger/metabolism
  • Intracellular Signaling Peptides and Proteins
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/metabolism*
  • Humans
  • Luminescent Proteins/biosynthesis
  • Luminescent Proteins/genetics
  • Coculture Techniques
  • Gene Silencing
  • Cell Movement
  • Animals
  • Animals, Genetically Modified
  • Receptors, Notch/genetics
  • Receptors, Notch/metabolism*
  • Cell Proliferation
  • Embryo, Nonmammalian/metabolism
  • Gene Expression Regulation, Developmental
  • Gene Knockdown Techniques
  • Chlorocebus aethiops
  • COS Cells
  • Thoracic Duct/embryology
  • Thoracic Duct/metabolism
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
  • Lymphatic System/embryology
  • Lymphatic System/metabolism*
(all 33)
PubMed
20466977 Full text @ Arterioscler. Thromb. Vasc. Biol.
Abstract
OBJECTIVE: To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development. METHODS AND RESULTS: In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal lymphangioblasts; instead, sprouts connecting to the intersomitic vessels were formed. At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates. CONCLUSIONS: These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network.
Genes / Markers
Figures
No images available
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Expression
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
hu4453TgTransgenic Insertion
    hu4624TgTransgenic Insertion
      s916TgTransgenic Insertion
        um13TgTransgenic Insertion
          um14TgTransgenic Insertion
            y1TgTransgenic Insertion
              1 - 6 of 6
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              Human Disease / Model
              No data available
              Sequence Targeting Reagents
              Target Reagent Reagent Type
              dlaMO3-dlaMRPHLNO
              dlbMO1-dlbMRPHLNO
              dlcMO5-dlcMRPHLNO
              dldMO3-dldMRPHLNO
              dll4MO3-dll4MRPHLNO
              dll4MO4-dll4MRPHLNO
              dll4MO5-dll4MRPHLNO
              jag1aMO3-jag1aMRPHLNO
              jag1bMO1-jag1bMRPHLNO
              jag2bMO1-jag2bMRPHLNO
              1 - 10 of 18
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              Fish
              Antibodies
              No data available
              Orthology
              No data available
              Engineered Foreign Genes
              Marker Marker Type Name
              DsRedEFGDsRed
              DsRedxEFGDsRedx
              EGFPEFGEGFP
              mCherryEFGmCherry
              YFPEFGYFP
              1 - 5 of 5
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              Mapping
              No data available