ZFIN Morpholino: MO3-cxcl12a

Target Location

Genome Build: GRCz11Chromosome: 13

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-cxcl12a

No data available

Phenotype

Phenotype resulting from MO3-cxcl12a

Phenotype	Fish	Figures
cell migration involved in gastrulation delayed, abnormal	ha01Tg + MO3-cxcl12a	Fig. S2 from Mizoguchi et al., 2008
hematopoietic system vasculature increased amount, abnormal	pd27Tg; zf741Tg + MO3-cxcl12a	Fig. 7 from Theodore et al., 2017
primordial germ cell mislocalised, abnormal	er1Tg + MO3-cxcl12a	Fig. 4 from Boldajipour et al., 2008

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Phenotype of all Fish created by or utilizing MO3-cxcl12a

Phenotype	Fish	Conditions	Figures
primordial germ cell mislocalised, abnormal	er1Tg + MO3-cxcl12a	standard conditions	Fig. 4 from Boldajipour et al., 2008
cell migration involved in gastrulation delayed, abnormal	ha01Tg + MO3-cxcl12a	standard conditions	Fig. S2 from Mizoguchi et al., 2008
hematopoietic system vasculature increased amount, abnormal	pd27Tg; zf741Tg + MO3-cxcl12a	control	Fig. 7 from Theodore et al., 2017
hematopoietic system posterior region has number of hematopoietic multipotent progenitor cell, ameliorated	pd27Tg; zf741Tg + MO3-cxcl12a	chemical treatment by environment: MMP9 inhibitor I	Fig. 7 from Theodore et al., 2017
hematopoietic system posterior region EGFP expression amount, ameliorated	pd27Tg; zf741Tg + MO3-cxcl12a	chemical treatment by environment: MMP9 inhibitor I	Fig. 7 from Theodore et al., 2017

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Citations

Include unpublished citations

Theodore, L.N., Hagedorn, E.J., Cortes, M., Natsuhara, K., Liu, S.Y., Perlin, J.R., Yang, S., Daily, M.L., Zon, L.I., North, T.E. (2017) Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 8(5):1226-1241
Donà, E., Barry, J.D., Valentin, G., Quirin, C., Khmelinskii, A., Kunze, A., Durdu, S., Newton, L.R., Fernandez-Minan, A., Huber, W., Knop, M., and Gilmour, D. (2013) Directional tissue migration through a self-generated chemokine gradient. Nature. 503(7475):285-9
Lewellis, S.W., Nagelberg, D., Subedi, A., Staton, A., Leblanc, M., Giraldez, A., and Knaut, H. (2013) Precise SDF1-mediated cell guidance is achieved through ligand clearance and microRNA-mediated decay. The Journal of cell biology. 200(3):337-355
Hess, I., and Boehm, T. (2012) Intravital Imaging of Thymopoiesis Reveals Dynamic Lympho-Epithelial Interactions. Immunity. 36(2):298-309
Zhang, Y., Jin, H., Li, L., Qin, F.X., and Wen, Z. (2011) cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis. Blood. 118(15):4093-101
Bajoghli, B., Aghaallaei, N., Hess, I., Rode, I., Netuschil, N., Tay, B.H., Venkatesh, B., Yu, J.K., Kaltenbach, S.L., Holland, N.D., Diekhoff, D., Happe, C., Schorpp, M., and Boehm, T. (2009) Evolution of genetic networks underlying the emergence of thymopoiesis in vertebrates. Cell. 138(1):186-197
Mich, J.K., Blaser, H., Thomas, N.A., Firestone, A.J., Yelon, D., Raz, E., and Chen, J.K. (2009) Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Developmental Biology. 328(2):342-354
Boldajipour, B., Mahabaleshwar, H., Kardash, E., Reichman-Fried, M., Blaser, H., Minina, S., Wilson, D., Xu, Q., and Raz, E. (2008) Control of chemokine-guided cell migration by ligand sequestration. Cell. 132(3):463-473
Mizoguchi, T., Verkade, H., Heath, J.K., Kuroiwa, A., and Kikuchi, Y. (2008) Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation. Development (Cambridge, England). 135(15):2521-2529
Blaser, H., Reichman-Fried, M., Castanon, I., Dumstrei, K., Marlow, F.L., Kawakami, K., Solnica-Krezel, L., Heisenberg, C.P., and Raz, E. (2006) Migration of zebrafish primordial germ cells: a role for Myosin contraction and cytoplasmic flow. Developmental Cell. 11(5):613-627

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