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Xie et al., 2021 - Congenital Asplenia Interrupts Immune Homeostasis and Leads to Excessive Systemic Inflammation in Zebrafish

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Figure 1

Effects of congenital asplenia on inflammatory response in zebrafish larvae. (A) The expression of inflammatory response–related genes after pathogenic A. hydrophila infection in zebrafish larvae. (B) The expression of inflammatory response–related genes after LPS exposure. (C, D) The expression of Il1β, Il6, and Tnfα proteins after A. hydrophila challenge and LPS by ELISA. (E) A high aggregation of apoptotic cells was observed in the trunk of congenitally asplenic zebrafish by TUNEL assay. The white arrowhead indicates TUNEL-positive cells. Different letters (a, b, c, etc.) indicate significant differences (p < .05).

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Infect Microbiol