Gene
tnfa
- ID
- ZDB-GENE-050317-1
- Name
- tumor necrosis factor a (TNF superfamily, member 2)
- Symbol
- tnfa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within several processes, including fin regeneration; hematopoietic stem cell differentiation; and response to bacterium. Is active in extracellular space. Is expressed in several structures, including central nervous system; digestive system; eye; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to several human genes including LTA (lymphotoxin alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 267 figures from 208 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ihb497 | Allele with one delins | Exon 1 | Unknown | CRISPR | |
sa16250 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa43296 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
ue106 | Allele with one delins | Exon 4 | Unknown | CRISPR | |
zf3218 | Allele with one deletion | Unknown | Unknown | CRISPR | |
zf3818 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
zf4107 | Allele with one deletion | Exon 1 | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-tnfa | (2) | |
CRISPR2-tnfa | Smith et al., 2017 | |
CRISPR3-tnfa | Smith et al., 2017 | |
CRISPR4-tnfa | (2) | |
CRISPR5-tnfa | Zebrafish Nomenclature Committee | |
CRISPR6-tnfa | (3) | |
CRISPR7-tnfa | (2) | |
CRISPR8-tnfa | (2) | |
CRISPR9-tnfa | (2) | |
CRISPR10-tnfa | (2) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
asthma | Alliance | {Asthma, susceptibility to} | 600807 |
immunodeficiency 127 | Alliance | ?Immunodeficiency 127 | 620977 |
migraine | Alliance | {Migraine without aura, susceptibility to} | 157300 |
{Dementia, vascular, susceptibility to} | |||
{Malaria, cerebral, susceptibility to} | 611162 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Lymphotoxin-alpha | Tumour necrosis factor | Tumour necrosis factor domain | Tumour necrosis factor-like domain superfamily |
---|---|---|---|---|---|---|
UniProtKB:Q1L8A5 | InterPro PDB | 234 | ||||
UniProtKB:Q08CQ3 | InterPro | 234 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
TgBAC(tnfa:GFP) |
|
| 1 | (42) | |
Tg(TETRE:ifng1-2A-tnfa-2A-il1b-2A-Hsa.HIST1H2BJ-EGFP,ubb:LOXP-mCherry-LOXP,ins:mCherry) |
| 1 | (2) | ||
Tg(tnfa:Dendra) |
|
| 1 | Yang et al., 2023 | |
Tg(tnfa:EGFPF) |
|
| 1 | (27) | |
Tg(tnfa:emGFP) |
|
| 1 | (2) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-361O3 | ZFIN Curated Data | |
Contained in | BAC | CH211-127D20 | ZFIN Curated Data | |
Contained in | BAC | CH211-176D22 | ZFIN Curated Data | |
Encodes | cDNA | MGC:152825 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192241 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_212859 (1) | 1145 nt | ||
Genomic | GenBank:BX469886 (1) | 151598 nt | ||
Polypeptide | UniProtKB:Q08CQ3 (1) | 234 aa |
- Della Vecchia, S., Imbrici, P., Liantonio, A., Naef, V., Damiani, D., Licitra, R., Bernardi, S., Marchese, M., Santorelli, F.M. (2025) Dapagliflozin ameliorates Lafora disease phenotype in a zebrafish model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 183:117800117800
- Deng, L., Feng, Z., Li, X., Fan, L., Wu, X., Tavakoli, S., Zhu, Y., Ye, H., Wu, K. (2025) Exploring the potential mechanism of B-phycoerythrin on DSS-induced colitis and colitis-associated bone loss based on network pharmacology, molecular docking, and experimental validation. Scientific Reports. 15:54555455
- He, J., Xu, P., Xu, T., Yu, H., Wang, L., Chen, R., Zhang, K., Yao, Y., Xie, Y., Yang, Q., Wu, W., Sun, D., Wu, D. (2025) Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer's disease: targeting oxidative stress, inflammation, and the gut-brain axis. Frontiers in aging neuroscience. 16:15150921515092
- Katoch, S., Chhimwal, J., Singh, D., Kumar, D., Patial, V. (2025) Picrosides-rich fraction from Picrorhiza kurroa attenuates steatohepatitis in zebrafish and mice by modulating lipid metabolism and inflammation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 137:156368156368
- Li, X., Xiong, G., Luo, M., Mao, S., Zhang, R., Meng, Z., Li, J., Liao, X. (2025) Peptidoglycan recognition protein PGRP-5 is involved in immune defence and neuro-behavioral disorders in zebrafish embryos. PLoS One. 20:e0315714e0315714
- Liu, L., Hu, W., Kerman, F.D., Spaink, H.P. (2025) Toll-like receptor adaptor protein TIRAP has specialized roles in signaling, metabolic control and leukocyte migration upon wounding in zebrafish larvae. International journal of biological sciences. 21:823841823-841
- Naef, V., Damiani, D., Licitra, R., Marchese, M., Vecchia, S.D., Baggiani, M., Brogi, L., Galatolo, D., Landi, S., Santorelli, F.M. (2025) Modeling sacsin depletion in Danio Rerio offers new insight on retinal defects in ARSACS. Neurobiology of disease. :106793106793
- Nies, Y.H., Lim, W.L., Abd Karim, N., Yahaya, M.F., Teoh, S.L. (2025) Metallothionein II treatment mitigates rotenone-induced neurodegeneration in zebrafish models of Parkinson's disease. Frontiers in pharmacology. 16:14780131478013
- Sebo, D.J., Ali, I., Fetsko, A.R., Trimbach, A.A., Taylor, M.R. (2025) Activation of Wnt/β-catenin in neural progenitor cells regulates blood-brain barrier development and promotes neuroinflammation. Scientific Reports. 15:34963496
- Vaz-Rodrigues, R., Mazuecos, L., Contreras, M., González-García, A., Rafael, M., Villar, M., de la Fuente, J. (2025) Tick salivary proteins metalloprotease and allergen-like p23 are associated with response to glycan α-Gal and mycobacterium infection. Scientific Reports. 15:88498849
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