Gene

tnfa

ID
ZDB-GENE-050317-1
Name
tumor necrosis factor a (TNF superfamily, member 2)
Symbol
tnfa Nomenclature History
Previous Names
  • TNF1 (1)
  • TNF-alpha 1 (1)
  • tnf-alpha
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable cytokine activity. Acts upstream of or within several processes, including fin regeneration; hematopoietic stem cell differentiation; and response to bacterium. Is active in extracellular space. Is expressed in several structures, including central nervous system; digestive system; eye; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to several human genes including LTA (lymphotoxin alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
267 figures from 208 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ihb497Allele with one delinsExon 1UnknownCRISPR
sa16250Allele with one point mutationUnknownSplice SiteENU
sa43296Allele with one point mutationUnknownPremature StopENU
ue106Allele with one delinsExon 4UnknownCRISPR
zf3218Allele with one deletionUnknownUnknownCRISPR
zf3818Allele with one deletionExon 1UnknownCRISPR
zf4107Allele with one deletionExon 1UnknownCRISPR
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Sequence Targeting Reagents
1 - 10 of 21
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Human Disease
Associated With tnfa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
asthma Alliance {Asthma, susceptibility to} 600807
immunodeficiency 127 Alliance ?Immunodeficiency 127 620977
migraine Alliance {Migraine without aura, susceptibility to} 157300
{Dementia, vascular, susceptibility to}
{Malaria, cerebral, susceptibility to} 611162
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Associated With tnfa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006052 Tumour necrosis factor domain
Family IPR002960 Lymphotoxin-alpha
Family IPR006053 Tumour necrosis factor
Homologous_superfamily IPR008983 Tumour necrosis factor-like domain superfamily
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Domain Details Per Protein
Protein Additional Resources Length Lymphotoxin-alpha Tumour necrosis factor Tumour necrosis factor domain Tumour necrosis factor-like domain superfamily
UniProtKB:Q1L8A5 InterPro PDB 234
UniProtKB:Q08CQ3 InterPro 234
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 19
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tnfa-201 (1) Ensembl 1,048 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tnfa polyclonal IgG Rabbit
  • IHC
AnaSpec
15
1 - 1 of 1
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
TgBAC(tnfa:GFP)
  • tnfa
  • Danio rerio
1 (42)
Tg(TETRE:ifng1-2A-tnfa-2A-il1b-2A-Hsa.HIST1H2BJ-EGFP,ubb:LOXP-mCherry-LOXP,ins:mCherry)
  • Danio rerio
  • Homo sapiens
1 (2)
Tg(tnfa:Dendra)
  • tnfa
  • Danio rerio
1Yang et al., 2023
Tg(tnfa:EGFPF)
  • tnfa
  • Danio rerio
1 (27)
Tg(tnfa:emGFP)
  • tnfa
  • Danio rerio
1 (2)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-361O3ZFIN Curated Data
Contained inBACCH211-127D20ZFIN Curated Data
Contained inBACCH211-176D22ZFIN Curated Data
EncodescDNAMGC:152825ZFIN Curated Data
EncodescDNAMGC:192241ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanTNF6
Conserved genome location (synteny) (2)
Phylogenetic tree (2)
Amino acid sequence comparison (5)
MouseTnf17
Amino acid sequence comparison (3)
Phylogenetic tree (1)
Citations
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