Gene
il10
- ID
- ZDB-GENE-051111-1
- Name
- interleukin 10
- Symbol
- il10 Nomenclature History
- Previous Names
-
- zgc:194510
- zgc:194518
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within several processes, including regulation of Notch signaling pathway; regulation of intestinal epithelial cell development; and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in blood; digestive system; gill; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to human IL10 (interleukin 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 73 figures from 57 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| e46 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ihb422 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| sa1423 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21894 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44739 | Allele with one point mutation | Unknown | Unknown | ENU | |
| uu1751 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
| uu1762 | Allele with one delins | Exon 3 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-il10 | Zebrafish Nomenclature Committee | |
| CRISPR2-il10 | (2) | |
| CRISPR3-il10 | (2) | |
| MO1-il10 | N/A | Lu et al., 2024 |
| MO2-il10 | N/A | Niu et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| graft-versus-host disease | Alliance | {Graft-versus-host disease, protection against} | 614395 |
| rheumatoid arthritis | Alliance | {Rheumatoid arthritis, progression of} | 180300 |
| {HIV-1, susceptibility to} | 609423 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core | Interleukin-10 | Interleukin-10/19/20/24/26 |
|---|---|---|---|---|---|
| UniProtKB:Q5EFQ8 | InterPro | 180 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-158F7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194510 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194518 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020785 (1) | 543 nt | ||
| Genomic | GenBank:CU459075 (2) | 179501 nt | ||
| Polypeptide | UniProtKB:Q5EFQ8 (1) | 180 aa |
- He, J., Xu, P., Xu, T., Yu, H., Wang, L., Chen, R., Zhang, K., Yao, Y., Xie, Y., Yang, Q., Wu, W., Sun, D., Wu, D. (2025) Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer's disease: targeting oxidative stress, inflammation, and the gut-brain axis. Frontiers in aging neuroscience. 16:15150921515092
- Liu, L., Hu, W., Kerman, F.D., Spaink, H.P. (2025) Toll-like receptor adaptor protein TIRAP has specialized roles in signaling, metabolic control and leukocyte migration upon wounding in zebrafish larvae. International journal of biological sciences. 21:823841823-841
- Araujo, M.H., Muñoz Sánchez, S., Simão, T.L.B.V., Nowik, N., Antunes, S.S., Pinto, S.C., Sorze, D., Boldrin, F., Manganelli, R., Correia Romeiro, N., Lasunskaia, E.B., Verbeek, F.J., Spaink, H.P., Muzitano, M.F. (2024) Exploring the Antimycobacterial Potential of Podocarpusflavone A from Kielmeyera membranacea: In Vitro and In Vivo Insights. Pharmaceuticals (Basel, Switzerland). 17(12):
- Brenet, A., Somkhit, J., Csaba, Z., Ciura, S., Kabashi, E., Yanicostas, C., Soussi-Yanicostas, N. (2024) Microglia Mitigate Neuronal Activation in a Zebrafish Model of Dravet Syndrome. Cells. 13(8):
- Brix, A., Belleri, L., Pezzotta, A., Pettinato, E., Mazzola, M., Zoccolillo, M., Marozzi, A., Monteiro, R., Del Bene, F., Mortellaro, A., Pistocchi, A. (2024) ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish. Communications biology. 7:615615
- Camussi, D., Naef, V., Brogi, L., Della Vecchia, S., Marchese, M., Nicoletti, F., Santorelli, F.M., Licitra, R. (2024) Delving into the Complexity of Valproate-Induced Autism Spectrum Disorder: The Use of Zebrafish Models. Cells. 13(16):
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- Guo, D., Xiong, H., Yang, Z., Zhang, R., Shi, P., Yao, Y., Liu, M., Xu, C., Wang, Q.K. (2024) Lysosomal membrane protein TMEM106B modulates hematopoietic stem and progenitor cell proliferation and differentiation by regulating LAMP2A stability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e23870e23870
- Kalaichelvan, A., Nadarajapillai, K., Sellaththurai, S.R., Arachchi, U.P.E., Kim, M.J., Jung, S., Lee, J. (2024) CRISPR/Cas9-induced knockout of tumor necrosis factor-alpha-type I augments viral infection in zebrafish. Fish & shellfish immunology. 157:110092110092
- Liu, Y., Lin, S., Wang, C., Li, T., Zheng, G., Sun, W., An, L., Bai, Y., Wu, F. (2024) Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Environmental science & technology. 58(35):15450-15462
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