Gene
opn1lw1
- ID
- ZDB-GENE-990604-41
- Name
- opsin 1 (cone pigments), long-wave-sensitive, 1
- Symbol
- opn1lw1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled photoreceptor activity. Acts upstream of or within photoperiodism. Predicted to be located in membrane. Predicted to be active in photoreceptor outer segment and plasma membrane. Is expressed in several structures, including digestive system; endocrine system; heart; photoreceptor cell; and visual system. Human ortholog(s) of this gene implicated in blue cone monochromacy; red color blindness; and red-green color blindness. Orthologous to several human genes including OPN1LW (opsin 1, long wave sensitive).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 72 figures from 47 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73027 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
blue cone monochromacy | Alliance | Blue cone monochromacy | 303700 |
red color blindness | Alliance | Colorblindness, protan | 303900 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G-protein coupled receptor opsins | G protein-coupled receptor, rhodopsin-like | Opsin | Opsin red/green sensitive | Visual pigments (opsins) retinal binding site |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A0N9N7J4 | InterPro | 357 | ||||||
UniProtKB:Q9W6A7 | InterPro | 357 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
opn1lw1-201
(1)
|
Ensembl | 1,699 nt | ||
ncRNA |
opn1lw1-002
(1)
|
Ensembl | 127 nt |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-opn1lw1 | polyclonal | Rabbit |
|
19 | |||
Ab2-opn1lw1 |
|
ABclonal
|
1 |
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Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(-0.6opn1lw1-opn1lw2:GFP) |
|
| 5 | (6) | |
Tg(-0.6opn1lw1-krt8:GFP) |
|
| 2 | (2) | |
Tg1PAC(opn1lw1:GFP,opn1lw2:DsRedx) |
|
| 1 | (4) | |
Tg(-2.6opn1lw1:GFP) |
|
| 3 | (4) | |
Tg(-2.6opn1lw1:GFP,-1.8opn1lw2:DsRedx) |
|
| 3 | (4) | |
Tg2PAC(opn1lw1:GFP,opn1lw2:DsRedx) |
|
| 1 | (8) | |
Tg3PAC(opn1lw1:GFP,opn1lw2:DsRedx) |
|
| 2 | (4) | |
Tg4PAC(opn1lw1:GFP,opn1lw2:DsRedx) |
|
| 2 | (4) | |
TgBAC(opn1lw1:opn1lw1-mNeonGreen,opn1lw2:opn1lw2-mKate2) |
|
|
| 1 | (3) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-13A21 | ||
Contained in | BAC | DKEY-245F22 | ZFIN Curated Data | |
Encodes | cDNA | MGC:73027 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001313715 (1) | 1732 nt | ||
Genomic | GenBank:AL844847 (1) | 235174 nt | ||
Polypeptide | UniProtKB:A0A0N9N7J4 (1) | 357 aa |
- Cao, M., Xu, T., Song, Y., Wei, S., Wang, H., Guo, X., Yin, D. (2024) Brominated Flame Retardant HBCD and Artificial Light at Night Synergically Caused Visual Disorder and Sleep Difficulty in Zebrafish Larvae. Environmental science & technology. 58(39):17247-17258
- Hu, H., Qin, Y., Qu, Z., Huang, Y., Ren, X., Liu, M., Liu, F., Gao, P. (2024) The Zpr-3 Antibody Recognizes the 320-354 Region of Rho and Labels Both Rods and Green Cones in Zebrafish. Zebrafish. 21(6):394-400
- Jing, Y., Luo, Y., Li, L., Liu, M., Liu, J.X. (2024) Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell biology and toxicology. 40:22
- Lazcano, I., Pech-Pool, S.M., Maldonado-Lira, M.F., Olvera, A., Darras, V.M., Orozco, A. (2024) Ontogeny of Thyroid Hormone Signaling in the Retina of Zebrafish: Effects of Thyroidal Status on Retinal Morphology, Cell Survival, and Color Preference. International Journal of Molecular Sciences. 25(22):
- Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024) Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121
- Angueyra, J.M., Kunze, V.P., Patak, L.K., Kim, H., Kindt, K., Li, W. (2023) Transcription factors underlying photoreceptor diversity. eLIFE. 12:
- Lu, K., Liang, X.F., Tang, S.L., Wu, J., Zhang, L., Wang, Y., Chai, F. (2023) Role of short-wave-sensitive 1 (sws1) in cone development and first feeding in larval zebrafish. Fish physiology and biochemistry. 49(5):801-813
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Biochemical and Biophysical Research Communications. 664:100107100-107
- Wang, Y.Y., Liang, X.F., Lu, K. (2023) Knockout of SWS2 in zebrafish (Danio rerio) reveals its roles in feeding and phototactic behaviors. Gene. 897:148059
- Wu, Y., Liu, W., Li, L., Tai, Z., Gao, B., Liu, J.X. (2023) Atp7b deficiency induces zebrafish eye developmental defects. Metallomics : integrated biometal science. 15(5):
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