Gene
opn1lw2
- ID
- ZDB-GENE-040718-141
- Name
- opsin 1 (cone pigments), long-wave-sensitive, 2
- Symbol
- opn1lw2 Nomenclature History
- Previous Names
-
- zgc:92632 (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and detection of light stimulus. Predicted to act upstream of or within signal transduction and visual perception. Predicted to be located in membrane. Predicted to be active in photoreceptor outer segment and plasma membrane. Is expressed in several structures, including endocrine system; heart; liver; red sensitive photoreceptor cell; and visual system. Human ortholog(s) of this gene implicated in blue cone monochromacy; red color blindness; and red-green color blindness. Orthologous to several human genes including OPN1LW (opsin 1, long wave sensitive).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G-protein coupled receptor opsins | G protein-coupled receptor, rhodopsin-like | Opsin | Opsin red/green sensitive | Visual pigments (opsins) retinal binding site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8AYN0 | InterPro | 356 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
opn1lw2-201
(1)
|
Ensembl | 1,642 nt | ||
| ncRNA |
opn1lw2-002
(1)
|
Ensembl | 817 nt | ||
| ncRNA |
opn1lw2-003
(1)
|
Ensembl | 862 nt | ||
| ncRNA |
opn1lw2-004
(1)
|
Ensembl | 934 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-0.6opn1lw1-opn1lw2:GFP) |
|
| 5 | (6) | |
| Tg(-1.8opn1lw2:GFP) |
|
| 1 | (2) | |
| Tg1PAC(opn1lw1:GFP,opn1lw2:DsRedx) |
|
| 1 | (4) | |
| Tg(-2.6opn1lw1:GFP,-1.8opn1lw2:DsRedx) |
|
| 3 | (4) | |
| Tg2PAC(opn1lw1:GFP,opn1lw2:DsRedx) |
|
| 1 | (8) | |
| Tg3PAC(opn1lw1:GFP,opn1lw2:DsRedx) |
|
| 2 | (4) | |
| Tg4PAC(opn1lw1:GFP,opn1lw2:DsRedx) |
|
| 2 | (4) | |
| TgBAC(opn1lw1:opn1lw1-mNeonGreen,opn1lw2:opn1lw2-mKate2) |
|
|
| 1 | (3) |
| Tg(opn1lw2:NfsB-mCherry) |
|
| 1 | (2) | |
| Tg(opn1lw2:NTR-mCherry) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-13A21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-245F22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92632 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002443 (1) | 1594 nt | ||
| Genomic | GenBank:AL844847 (1) | 235174 nt | ||
| Polypeptide | UniProtKB:Q8AYN0 (1) | 356 aa |
No data available
- Cao, M., Xu, T., Song, Y., Wei, S., Wang, H., Guo, X., Yin, D. (2024) Brominated Flame Retardant HBCD and Artificial Light at Night Synergically Caused Visual Disorder and Sleep Difficulty in Zebrafish Larvae. Environmental science & technology. 58(39):17247-17258
- Fagundes, T., Pannetier, P., Gölz, L., Behnstedt, L., Morthorst, J., Vergauwen, L., Knapen, D., Holbech, H., Braunbeck, T., Baumann, L. (2024) The generation gap in endocrine disruption: Can the integrated fish endocrine disruptor test (iFEDT) bridge the gap by assessing intergenerational effects of thyroid hormone system disruption?. Aquatic toxicology (Amsterdam, Netherlands). 272:106969106969
- Hu, H., Qin, Y., Qu, Z., Huang, Y., Ren, X., Liu, M., Liu, F., Gao, P. (2024) The Zpr-3 Antibody Recognizes the 320-354 Region of Rho and Labels Both Rods and Green Cones in Zebrafish. Zebrafish. 21(6):394-400
- Lazcano, I., Pech-Pool, S.M., Maldonado-Lira, M.F., Olvera, A., Darras, V.M., Orozco, A. (2024) Ontogeny of Thyroid Hormone Signaling in the Retina of Zebrafish: Effects of Thyroidal Status on Retinal Morphology, Cell Survival, and Color Preference. International Journal of Molecular Sciences. 25(22):
- Volkov, L.I., Ogawa, Y., Somjee, R., Vedder, H.E., Powell, H.E., Poria, D., Meiselman, S., Kefalov, V.J., Corbo, J.C. (2024) Samd7 represses short-wavelength cone genes to preserve long-wavelength cone and rod photoreceptor identity. Proceedings of the National Academy of Sciences of the United States of America. 121:e2402121121e2402121121
- Yang, H.Z., Zhuo, D., Huang, Z., Luo, G., Liang, S., Fan, Y., Zhao, Y., Lv, X., Qiu, C., Zhang, L., Liu, Y., Sun, T., Chen, X., Li, S.S., Jin, X. (2024) Deficiency of Acetyltransferase nat10 in Zebrafish Causes Developmental Defects in the Visual Function. Investigative ophthalmology & visual science. 65:3131
- Zheng, N., Liao, T., Zhang, C., Zhang, Z., Yan, S., Xi, X., Ruan, F., Yang, C., Zhao, Q., Deng, W., Huang, J., Huang, Z.T., Chen, Z.F., Wang, X., Qu, Q., Zuo, Z., He, C. (2024) Quantum Dots-caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 11(46):e2406343
- Angueyra, J.M., Kunze, V.P., Patak, L.K., Kim, H., Kindt, K., Li, W. (2023) Transcription factors underlying photoreceptor diversity. eLIFE. 12:
- Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273
- Lu, K., Liang, X.F., Tang, S.L., Wu, J., Zhang, L., Wang, Y., Chai, F. (2023) Role of short-wave-sensitive 1 (sws1) in cone development and first feeding in larval zebrafish. Fish physiology and biochemistry. 49(5):801-813
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