Gene

dld

ID
ZDB-GENE-990415-47
Name
deltaD
Symbol
dld Nomenclature History
Previous Names
  • aei
  • after eight
  • sc:d0402
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Enables PDZ domain binding activity. Acts upstream of or within several processes, including determination of left/right symmetry; somite development; and ventral spinal cord development. Located in perinuclear region of cytoplasm and plasma membrane. Is expressed in several structures, including gut; mesoderm; nervous system; presumptive mesoderm; and tail bud. Orthologous to human DLL1 (delta like canonical Notch ligand 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
89 figures from 71 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
23 figures from 16 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
dld_unspecifiedUnspecified AlleleUnknownUnknownnot specified
ion30hAllele with one delinsExon 2UnknownCRISPR
sa15390Allele with one point mutationUnknownPremature StopENU
sa22208Allele with one point mutationUnknownPremature StopENU
sa45480Allele with one point mutationUnknownPremature StopENU
tg22aunknownUnknownUnknownENU
tg249Allele with one point mutationUnknownUnknownENU
tm223unknownUnknownUnknownENU
tr233Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
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Human Disease
Associated With dld Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures 618709
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Associated With dld Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001774 Delta/Serrate/lag-2 (DSL) protein
Domain IPR001881 EGF-like calcium-binding domain
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Domain Details Per Protein
Protein Additional Resources Length Delta/Serrate/lag-2 (DSL) protein EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Notch ligand, N-terminal domain Notch Signaling and Cell Fate Determination
UniProtKB:A1L1P2 InterPro 717
UniProtKB:Q8UWJ4 InterPro 717
UniProtKB:A0A8M1P6G0 InterPro 717
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 13
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA dld-201 (1) Ensembl 3,339 nt
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Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-dld monoclonal IgG1 Mouse
  • IHC
  • WB
Abcam plc
20
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Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(-1.2dld:dld-mCherry)
  • dld
  • Danio rerio
1 (4)
Tg(-1.3dld:GFP)
  • dld
  • Danio rerio
1 (4)
Tg(-1.8dld:GFP)
  • dld
  • Danio rerio
1 (4)
Tg1(dld:GFP)
  • dld
  • Danio rerio
1 (4)
Tg2(dld:GFP)
  • dld
  • Danio rerio
1 (4)
Tg(-3.5dld:GFP)
  • dld
  • Danio rerio
1 (6)
Tg3(dld:GFP)
  • dld
  • Danio rerio
1 (4)
Tg4(dld:GFP)
  • dld
  • Danio rerio
1 (5)
Tg5(dld:GFP)
  • dld
  • Danio rerio
1 (4)
Tg(-6dld:GFP)
  • dld
  • Danio rerio
1 (6)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-241D9ZFIN Curated Data
EncodescDNAcssl:d402Bushell et al., 2007
EncodescDNAMGC:158216ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanDLL16
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseDll117
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
Phylogenetic tree (1)
Citations
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