Gene
dld
- ID
- ZDB-GENE-990415-47
- Name
- deltaD
- Symbol
- dld Nomenclature History
- Previous Names
-
- aei
- after eight
- sc:d0402
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables PDZ domain binding activity. Acts upstream of or within several processes, including determination of left/right symmetry; somite development; and ventral spinal cord development. Located in perinuclear region of cytoplasm and plasma membrane. Is expressed in several structures, including gut; mesoderm; nervous system; presumptive mesoderm; and tail bud. Orthologous to human DLL1 (delta like canonical Notch ligand 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 89 figures from 71 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 16 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
dld_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
ion30h | Allele with one delins | Exon 2 | Unknown | CRISPR | |
sa15390 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa22208 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa45480 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
tg22a | unknown | Unknown | Unknown | ENU | |
tg249 | Allele with one point mutation | Unknown | Unknown | ENU | |
tm223 | unknown | Unknown | Unknown | ENU | |
tr233 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-dld | Jin et al., 2022 | |
CRISPR2-dld | Jin et al., 2022 | |
CRISPR3-dld | Jin et al., 2022 | |
CRISPR4-dld | Jin et al., 2022 | |
MO1-dld | N/A | (4) |
MO2-dld | N/A | (15) |
MO3-dld | N/A | (3) |
MO4-dld | N/A | Cau et al., 2008 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures | 618709 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Notch ligand, N-terminal domain | Notch Signaling and Cell Fate Determination |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A1L1P2 | InterPro | 717 | |||||||||
UniProtKB:Q8UWJ4 | InterPro | 717 | |||||||||
UniProtKB:A0A8M1P6G0 | InterPro | 717 |
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Interactions and Pathways
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(-1.2dld:dld-mCherry) |
|
|
| 1 | (4) |
Tg(-1.3dld:GFP) |
|
| 1 | (4) | |
Tg(-1.8dld:GFP) |
|
| 1 | (4) | |
Tg1(dld:GFP) |
|
| 1 | (4) | |
Tg2(dld:GFP) |
|
| 1 | (4) | |
Tg(-3.5dld:GFP) |
|
| 1 | (6) | |
Tg3(dld:GFP) |
|
| 1 | (4) | |
Tg4(dld:GFP) |
|
| 1 | (5) | |
Tg5(dld:GFP) |
|
| 1 | (4) | |
Tg(-6dld:GFP) |
|
| 1 | (6) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | Fosmid | CH1073-241D9 | ZFIN Curated Data | |
Encodes | cDNA | cssl:d402 | Bushell et al., 2007 | |
Encodes | cDNA | MGC:158216 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_130955 (1) | 3339 nt | ||
Genomic | GenBank:CU855920 (1) | 41907 nt | ||
Polypeptide | UniProtKB:A0A8M1P6G0 (1) | 717 aa |
- Bell, J.M., Turner, E.M., Biesemeyer, C., Vanderbeck, M.M., Hendricks, R., McGraw, H.F. (2024) foxg1a is required for hair cell development and regeneration in the zebrafish lateral line. Biology Open. 13(9):
- Nian, F.S., Liao, B.K., Su, Y.L., Wu, P.R., Tsai, J.W., Hou, P.S. (2024) Oscillatory DeltaC Expression in Neural Progenitors Primes the Prototype of Forebrain Development. Molecular neurobiology. :
- Megerson, E., Kuehn, M., Leifer, B., Bell, J.M., Snyder, J.L., McGraw, H.F. (2023) Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line. iScience. 27:108678108678
- Silva, N., Campinho, M.A. (2023) In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity. Frontiers in endocrinology. 14:11576851157685
- Song, K., Lin, Z., Cao, L., Lu, B., Chen, Y., Zhang, S., Lu, J., Xu, H. (2023) Sox11b regulates the migration and fate determination of Müller glia-derived progenitors during retina regeneration in zebrafish. Neural regeneration research. 18:445-450
- Alhashem, Z., Feldner-Busztin, D., Revell, C., Alvarez-Garcillan Portillo, M., Camargo-Sosa, K., Richardson, J., Rocha, M., Gauert, A., Corbeaux, T., Milanetto, M., Argenton, F., Tiso, N., Kelsh, R., Prince, V.E., Bentley, K., Linker, C. (2022) Notch controls the cell cycle to define leader versus follower identities during collective cell migration. eLIFE. 11:
- Hevia, C.F., Engel-Pizcueta, C., Udina, F., Pujades, C. (2022) The neurogenic fate of the hindbrain boundaries relies on Notch3-dependent asymmetric cell divisions. Cell Reports. 39:110915
- Jin, M., Zhang, H., Xu, B., Li, Y., Qin, H., Yu, S., He, J. (2022) Jag2b-Notch3/1b-mediated neuron-to-glia crosstalk controls retinal gliogenesis. EMBO reports. 23(10):e54922
- Kraus, J.M., Giovannone, D., Rydzik, R., Balsbaugh, J.L., Moss, I.L., Schwedler, J.L., Bertrand, J.Y., Traver, D., Hankenson, K.D., Crump, J.G., Youngstrom, D.W. (2022) Notch signaling enhances bone regeneration in the zebrafish mandible. Development (Cambridge, England). 149(5)
- Li, Y., Wang, C., Zhang, L., Chen, B., Mo, Y., Zhang, J. (2022) Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids and barriers of the CNS. 19:40
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