Gene

crb2b

ID
ZDB-GENE-060610-1
Name
crumbs cell polarity complex component 2b
Symbol
crb2b Nomenclature History
Previous Names
  • crb2l (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable calcium ion binding activity. Involved in retina morphogenesis in camera-type eye. Acts upstream of or within several processes, including glomerular filtration; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and kidney development. Located in plasma membrane. Part of protein-containing complex. Is expressed in nervous system and pronephros. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 9 and ventriculomegaly - cystic kidney disease. Orthologous to human CRB2 (crumbs cell polarity complex component 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With crb2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
focal segmental glomerulosclerosis 9 Alliance Focal segmental glomerulosclerosis 9 616220
ventriculomegaly - cystic kidney disease Alliance Ventriculomegaly with cystic kidney disease 219730
1 - 2 of 2
Associated With crb2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001791 Laminin G domain
Domain IPR001881 EGF-like calcium-binding domain
1 - 5 of 9 Show all
Domain Details Per Protein
Protein Additional Resources Length Concanavalin A-like lectin/glucanase domain superfamily EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Laminin G domain Notch Signaling and Cell Fate Determination
UniProtKB:Q1A5L1 InterPro 1458
UniProtKB:A0A8M6Z842 InterPro 1458
UniProtKB:A0AB32TWW2 InterPro 1458
1 - 3 of 3
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-crb Rabbit
  • IHC
2
Ab1-crb2b polyclonal Rabbit
  • IHC
10
Ab1-crb Rabbit
  • IHC
  • WB
5
1 - 3 of 3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations