Gene
crb1
- ID
- ZDB-GENE-050208-382
- Name
- crumbs cell polarity complex component 1
- Symbol
- crb1 Nomenclature History
- Previous Names
-
- si:dkey-114d20.6
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within cell projection morphogenesis and establishment or maintenance of epithelial cell apical/basal polarity. Part of protein-containing complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| icm31 | Allele with one deletion | Exon 2 | Frameshift | CRISPR | |
| ihb443 | Allele with one insertion | Exon 3 | Unknown | CRISPR | |
| ihb444 | Allele with one delins | Exon 3 | Unknown | CRISPR | |
| la011281Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022267Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa159 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa1482 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12558 | Allele with one point mutation | Exon 6 | Premature Stop | ENU | |
| sa14330 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24173 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 10 of 12
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-crb1 | Desban et al., 2019 | |
| CRISPR2-crb1 | Zebrafish Nomenclature Committee | |
| MO1-crb1 | N/A | Zou et al., 2013 |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Leber congenital amaurosis 8 | Alliance | Leber congenital amaurosis 8 | 613835 |
| pigmented paravenous chorioretinal atrophy | Alliance | Pigmented paravenous chorioretinal atrophy | 172870 |
| retinitis pigmentosa 12 | Alliance | Retinitis pigmentosa-12 | 600105 |
1 - 3 of 3
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Laminin G domain | Notch Signaling and Cell Fate Determination |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B8L0 | InterPro | 1042 | |||||||||
| UniProtKB:Q1A5L3 | InterPro | 1428 | |||||||||
| UniProtKB:A0AB32TEP1 | InterPro | 1428 |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-189A7 | ZFIN Curated Data | |
| Contained in | BAC | CH211-195I21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-114D20 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195113 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044943 (1) | 4427 nt | ||
| Genomic | GenBank:CR628370 (1) | 190967 nt | ||
| Polypeptide | UniProtKB:A0AB32TEP1 (1) | 1428 aa |
- Prendergast, A.E., Jim, K.K., Marnas, H., Desban, L., Quan, F.B., Djenoune, L., Laghi, V., Hocquemiller, A., Lunsford, E.T., Roussel, J., Keiser, L., Lejeune, F.X., Dhanasekar, M., Bardet, P.L., Levraud, J.P., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Wyart, C. (2023) CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current biology : CB. 33(5):940-956.e10
- Guo, C., Deveau, C., Zhang, C., Nelson, R., Wei, X. (2020) Zebrafish Crb1, localizing uniquely to the cell membranes around cone photoreceptor axonemes, alleviates light damage to photoreceptors and modulates cones' light responsiveness. The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(37):7065-7079
- Hao, Y., Zhou, Y., Yu, Y., Zheng, M., Weng, K., Kou, Z., Liang, J., Zhang, Q., Tang, X., Xu, P., Link, B.A., Yao, K., Zou, J. (2020) Interplay of MPP5a with Rab11 synergistically builds epithelial apical polarity and zonula adherens. Development (Cambridge, England). 147(22):
- Chen, Z., Song, Z., Yang, J., Huang, J., Jiang, H. (2019) Sp7/osterix positively regulates dlx2b and bglap to affect tooth development and bone mineralization in zebrafish larvae. Journal of biosciences. 44(6):
- Desban, L., Prendergast, A., Roussel, J., Rosello, M., Geny, D., Wyart, C., Bardet, P.L. (2019) Regulation of the apical extension morphogenesis tunes the mechanosensory response of microvilliated neurons. PLoS Biology. 17:e3000235
- Sharma, P., Saraswathy, V.M., Xiang, L., Fürthauer, M. (2019) Notch-mediated inhibition of neurogenesis is required for zebrafish spinal cord morphogenesis. Scientific Reports. 9:9958
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Zou, J., Wen, Y., Yang, X., and Wei, X. (2013) Spatial-temporal expressions of Crumbs and Nagie oko and their interdependence in zebrafish central nervous system during early development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 31(8):770-782
- Zou, J., Wang, X., and Wei, X. (2012) Crb Apical Polarity Proteins Maintain Zebrafish Retinal Cone Mosaics via Intercellular Binding of Their Extracellular Domains. Developmental Cell. 22(6):1261-1274
- Ohata, S., Aoki, R., Kinoshita, S., Yamaguchi, M., Tsuruoka-Kinoshita, S., Tanaka, H., Wada, H., Watabe, S., Tsuboi, T., Masai, I., and Okamoto, H. (2011) Dual Roles of Notch in Regulation of Apically Restricted Mitosis and Apicobasal Polarity of Neuroepithelial Cells. Neuron. 69(2):215-230
1 - 10 of 15
Show