Gene
flt1
- ID
- ZDB-GENE-050407-1
- Name
- fms related receptor tyrosine kinase 1
- Symbol
- flt1 Nomenclature History
- Previous Names
-
- flt1a (1)
- VEGFR1
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable growth factor binding activity and vascular endothelial growth factor receptor activity. Acts upstream of or within blood vessel development; establishment of left/right asymmetry; and regulation of heart contraction. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in angioblastic mesenchymal cell; brain; cardiovascular system; endothelial cell; and somite. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; bronchopulmonary dysplasia; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns29 | Allele with one delins | Exon 3 | Premature Stop | CRISPR | |
| fh338 | Allele with one point mutation | Unknown | Unknown | ENU | |
| fh390 | unknown | Unknown | Unknown | not specified | |
| flt1_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
| ka601 | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | CRISPR | |
| ka602 | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | CRISPR | |
| ka603 | Allele with one insertion | Exon 3 | Frameshift, Premature Stop | CRISPR | |
| ka604 | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | CRISPR | |
| ka605 | Allele with one insertion | Exon 11 | Frameshift, Premature Stop | CRISPR | |
| ka606 | Allele with one insertion | Exon 11 | Frameshift, Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-flt1 | (6) | |
| CRISPR2-flt1 | (6) | |
| CRISPR3-flt1 | (2) | |
| CRISPR4-flt1 | Wild et al., 2017 | |
| CRISPR5-flt1 | (2) | |
| CRISPR6-flt1 | Wild et al., 2017 | |
| CRISPR7-flt1 | Wild et al., 2017 | |
| CRISPR8-flt1 | Wild et al., 2017 | |
| CRISPR9-flt1 | Wild et al., 2017 | |
| MO1-flt1 | N/A | (5) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001824 | Tyrosine-protein kinase, receptor class III, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Platelet-derived growth factor receptor-like protein | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class III, conserved site | Vascular endothelial growth factor receptor 1 (VEGFR1) | VEGFR1-3, fifth immunoglobulin-like domain | VEGFR1-3, N-terminal Ig-like domain | VEGFR-2, transmembrane domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B3DKP1 | InterPro | 1272 | |||||||||||||||||||
| UniProtKB:F1QBD0 | InterPro | 473 |
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Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-flt1 | polyclonal | IgG | Rabbit |
|
Thermo Fisher Scientific (Lab Vision)
|
3 |
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Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-0.8flt1:flt1-2xHA) |
|
|
| 1 | Klems et al., 2020 |
| Tg(-0.8flt1:RFP) |
|
| 1 | (63) | |
| TgBAC(flt1:Citrine) |
|
| 2 | (30) | |
| Tg(flt1-2xHA-flt1) |
|
| 1 | Klems et al., 2020 | |
| Tg(flt1:EGFP) |
|
| 1 | Hashiura et al., 2017 | |
| Tg(flt1:EGFP-SV40) |
|
| 1 | Paulissen et al., 2022 | |
| Tg(flt1:GFP-TRION) |
|
| 1 | Klems et al., 2020 | |
| Tg(flt1:mCherry) |
|
| 1 | (2) | |
| Tg(flt1:Mmu.Fos-EGFP) |
|
| 1 | (10) | |
| Tg(flt1:NLS-mCherry) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-140B10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-33C18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162053 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195349 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001014829 (1) | 4254 nt | ||
| Genomic | GenBank:BX571696 (1) | 171175 nt | ||
| Polypeptide | UniProtKB:B3DKP1 (1) | 1272 aa |
- Chatterjee, B., Fatima, F., Seth, S., Sinha Roy, S. (2024) Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring. Cells. 13(3):
- Fernezelian, D., Pfitsch, S., Rastegar, S., Diotel, N. (2024) Mapping the cellular expression patterns of vascular endothelial growth factor aa and bb genes and their receptors in the adult zebrafish brain during constitutive and regenerative neurogenesis. Neural Development. 19:1717
- Schumacher, J.A., Wright, Z.A., Rufin Florat, D., Anand, S.K., Dasyani, M., Batta, S.P.R., Laverde, V., Ferrari, K., Klimkaite, L., Bredemeier, N.O., Gurung, S., Koller, G.M., Aguera, K.N., Chadwick, G.P., Johnson, R.D., Davis, G.E., Sumanas, S. (2024) SH2 domain protein E and ABL signaling regulate blood vessel size. PLoS Genetics. 20:e1010851e1010851
- Wang, Z.Y., Mehra, A., Wang, Q.C., Gupta, S., Ribeiro da Silva, A., Juan, T., Günther, S., Looso, M., Detleffsen, J., Stainier, D.Y.R., Marín-Juez, R. (2024) flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response. Development (Cambridge, England). 151(23):
- Zhang, J.L., Fan, D.G., Yin, W., Hu, B. (2024) CM082 suppresses hypoxia-induced retinal neovascularization in larval zebrafish. Frontiers in pharmacology. 15:13362491336249
- Da'as, S.I., Ahmed, I., Hasan, W.H., Abdelrahman, D.A., Aliyev, E., Nisar, S., Bhat, A.A., Joglekar, M.V., Hardikar, A.A., Fakhro, K.A., Akil, A.S.A. (2023) The link between glycemic control measures and eye microvascular complications in a clinical cohort of type 2 diabetes with microRNA-223-3p signature. Journal of translational medicine. 21:171171
- Deshmukh, D., Hsu, Y.F., Chiu, C.C., Jadhao, M., Hsu, S.C.N., Hu, S.Y., Yang, S.H., Liu, W. (2023) Antiangiogenic potential of Lepista nuda extract suppressing MAPK/p38 signaling-mediated developmental angiogenesis in zebrafish and HUVECs. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 159:114219114219
- He, Y., Kam, H., Wu, X., Chen, Q., Lee, S.M.Y. (2023) Dual effect of aucubin on promoting VEGFR2 mediated angiogenesis and reducing RANKL-induced bone resorption. Chinese Medicine. 18:108108
- Hipke, K., Pitter, B., Hruscha, A., van Bebber, F., Modic, M., Bansal, V., Lewandowski, S.A., Orozco, D., Edbauer, D., Bonn, S., Haass, C., Pohl, U., Montanez, E., Schmid, B. (2023) Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. Frontiers in cell and developmental biology. 11:11699621169962
- Parab, S., Card, O.A., Chen, Q., America, M., Buck, L.D., Quick, R.E., Horrigan, W.F., Levkowitz, G., Vanhollebeke, B., Matsuoka, R.L. (2023) Local angiogenic interplay of Vegfc/d and Vegfa controls brain region-specific emergence of fenestrated capillaries. eLIFE. 12:
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