Gene

casp9

ID
ZDB-GENE-030825-5
Name
caspase 9, apoptosis-related cysteine peptidase
Symbol
casp9 Nomenclature History
Previous Names
  • im:7136887
  • zgc:101776
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within several processes, including positive regulation of apoptotic process; regulation of collateral sprouting in absence of injury; and renal filtration. Predicted to be active in cytosol. Is expressed in several structures, including gut; liver; male organism; muscle; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (caspase 9).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
44 figures from 36 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa11164Allele with one point mutationUnknownSplice SiteENU
sa37709Allele with one point mutationUnknownSplice SiteENU
sa37710Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-casp9
    (2)
    CRISPR2-casp9
      (2)
      MO1-casp9N/A (4)
      MO2-casp9N/ACampbell et al., 2013
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      Human Disease
      Associated With casp9 Human Ortholog
      No data available
      Associated With casp9 Via Experimental Models
      No data available
      Gene Ontology
      Protein Domains
      Domain, Family, and Site Summary
      Type InterPro ID Name
      Active_site IPR016129 Peptidase family C14A, His active site
      Active_site IPR033139 Peptidase family C14A, cysteine active site
      Domain IPR001309 Peptidase C14, p20 domain
      Domain IPR001315 CARD domain
      Domain IPR002138 Peptidase C14, caspase non-catalytic subunit p10
      1 - 5 of 11 Show all
      Domain Details Per Protein
      Protein Additional Resources Length CARD domain CASP9, CARD domain Caspase-like domain superfamily Death-like domain superfamily Peptidase C14A, caspase catalytic domain Peptidase C14, caspase domain Peptidase C14, caspase non-catalytic subunit p10 Peptidase C14 family Peptidase C14, p20 domain Peptidase family C14A, cysteine active site Peptidase family C14A, His active site
      UniProtKB:F1QSB1 InterPro 436
      1 - 1 of 1
      Transcripts
      Genome Browsers
      Genome Build: GRCz11Chromosome: 23
      Type Name Annotation Method Has Havana Data Length (nt) Analysis
      mRNA casp9-201 (1) Ensembl 1,734 nt
      ncRNA casp9-002 (1) Ensembl 658 nt
      1 - 2 of 2
      Interactions and Pathways
      No data available
      Antibodies
      No data available
      Plasmids
      No data available
      Constructs
      Construct Regulatory Region Coding Sequence Species Tg Lines Citations
      Tg(5xUAS:EGFP-dncasp9,cryaa:RFP)
      • Danio rerio
      1 (3)
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      Marker Relationships
      Relationship Marker Type Marker Accession Numbers Citations
      Contained inBACDKEY-7I1ZFIN Curated Data
      EncodesESTIMAGE:7136887Thisse et al., 2004
      EncodesESTfc30h06
        ZFIN Curated Data
        EncodescDNAMGC:101776ZFIN Curated Data
        EncodescDNAMGC:114035ZFIN Curated Data
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        Sequences
        Orthology
        Comparative Orthology
        Alliance
        Gene Tree
        Ensembl
        Species Symbol Chromosome Accession # Evidence
        HumanCASP91
        Conserved genome location (synteny) (1)
        Amino acid sequence comparison (1)
        MouseCasp94
        Amino acid sequence comparison (1)
        Conserved genome location (synteny) (1)
        Citations
        1 - 10 of 191
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