Gene
casp9
- ID
- ZDB-GENE-030825-5
- Name
- caspase 9, apoptosis-related cysteine peptidase
- Symbol
- casp9 Nomenclature History
- Previous Names
-
- im:7136887
- zgc:101776
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within several processes, including positive regulation of apoptotic process; regulation of collateral sprouting in absence of injury; and renal filtration. Predicted to be active in cytosol. Is expressed in several structures, including gut; liver; male organism; muscle; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (caspase 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 36 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136887 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-casp9 | (2) | |
CRISPR2-casp9 | (2) | |
MO1-casp9 | N/A | (4) |
MO2-casp9 | N/A | Campbell et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR016129 | Peptidase family C14A, His active site |
Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
Domain | IPR001309 | Peptidase C14, p20 domain |
Domain | IPR001315 | CARD domain |
Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
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Domain Details Per Protein
Protein | Additional Resources | Length | CARD domain | CASP9, CARD domain | Caspase-like domain superfamily | Death-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14 family | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site | Peptidase family C14A, His active site |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:F1QSB1 | InterPro | 436 |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-7I1 | ZFIN Curated Data | |
Encodes | EST | IMAGE:7136887 | Thisse et al., 2004 | |
Encodes | EST | fc30h06 | ZFIN Curated Data | |
Encodes | cDNA | MGC:101776 | ZFIN Curated Data | |
Encodes | cDNA | MGC:114035 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001007404 (1) | 1733 nt | ||
Genomic | GenBank:CR376748 (1) | 233351 nt | ||
Polypeptide | UniProtKB:F1QSB1 (1) | 436 aa |
- Wang, C., Zhong, Y., Zhang, Y., Jiang, Y., Wang, C., An, L., Luo, C., Yang, L., He, Z., Yang, Y., Luo, M., Mao, M., Wang, W., Liu, Q., Shi, Y., Ping, Y.F. (2025) Cd248a regulates pericyte development and viability in zebrafish. Communications biology. 8:451451
- Cao, Y., Xu, F., Xia, Q., Liu, K., Lin, H., Zhang, S., Zhang, Y. (2024) The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways. Marine drugs. 22(3):
- de Calbiac, H., Renault, S., Haouy, G., Jung, V., Roger, K., Zhou, Q., Campanari, M.L., Chentout, L., Demy, D.L., Marian, A., Goudin, N., Edbauer, D., Guerrera, C., Ciura, S., Kabashi, E. (2024) Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects. Autophagy. 20:216421852164-2185
- Jiang, Z., Deng, L., Xiang, G., Xu, X., Wang, Y. (2024) A Mechanistic Study of the Osteogenic Effect of Arecoline in an Osteoporosis Model: Inhibition of Iron Overload-Induced Osteogenesis by Promoting Heme Oxygenase-1 Expression. Antioxidants (Basel, Switzerland). 13(4):
- Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Wang, Y., Sun, X., Xiong, B., Duan, M., Sun, Y. (2024) Genetic and Environmental Factors Co-Contributing to Behavioral Abnormalities in adnp/adnp2 Mutant Zebrafish. International Journal of Molecular Sciences. 25(17):
- Zhao, S., Mo, G., Wang, Q., Xu, J., Yu, S., Huang, Z., Liu, W., Zhang, W. (2024) Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b. Cell death discovery. 10:182182
- Accogli, A., Lin, S.J., Severino, M., Kim, S.H., Huang, K., Rocca, C., Landsverk, M., Zaki, M., Al-Maawali, A., Srinivasan, V.M., Al-Thihli, K., Schaefer, G.B., Davis, M., Tonduti, D., Doneda, C., Marten, L.M., Mühlhausen, C., Gomez, M., Lamantea, E., Mena, R., Nizon, M., Procaccio, V., Begtrup, A., Telegrafi, A., Cui, H., Schulz, H.L., Mohr, J., Biskup, S., Loos, M.A., Aráoz, H.V., Salpietro, V., Keppen, L.D., Chitre, M., Petree, C., Raymond, L., Vogt, J., Swayer, L.B., Basinger, A.A., Pedersen, S.V., Pearson, T.S., Grange, D.K., Lingapp, L., McDunnah, P., Horvath, R., Cogne, B., Isidor, B., Hahn, A., Gripp, K., Jafarnejad, S.M., Ostergaard, E., Prada, C.E., Ghezzi, D., Gowda, V.K., Taylor, R.W., Sonenberg, N., Houlden, H., Sissler, M., Varshney, G.K., Maroofian, R. (2023) Clinical, neuroradiological and molecular characterization of mitochondrial threonyl-tRNA-synthetase (TARS2)-related disorder. Genetics in medicine : official journal of the American College of Medical Genetics. 25(11):100938
- Huttner, I.G., Santiago, C.F., Jacoby, A., Cheng, D., Trivedi, G., Cull, S., Cvetkovska, J., Chand, R., Berger, J., Currie, P.D., Smith, K.A., Fatkin, D. (2023) Loss of Sec-1 Family Domain-Containing 1 (scfd1) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish. Journal of cardiovascular development and disease. 10(10):
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