Gene
pdgfrb
- ID
- ZDB-GENE-030805-2
- Name
- platelet-derived growth factor receptor, beta polypeptide
- Symbol
- pdgfrb Nomenclature History
- Previous Names
-
- pdgfrb2
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable platelet-derived growth factor beta-receptor activity and platelet-derived growth factor binding activity. Involved in several processes, including angiogenesis involved in coronary vascular morphogenesis; platelet-derived growth factor receptor-beta signaling pathway; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within several processes, including embryonic neurocranium morphogenesis; hematopoietic stem cell differentiation; and vasculature development. Predicted to be located in lysosomal lumen and membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; floor plate neural tube; hypochord; somite; and vasculature. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm; and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb440 | Allele with one deletion | Exon 4 | Unknown | CRISPR | |
| ihb452 | Allele with one delins | Exon 4 | Unknown | CRISPR | |
| ion33dTg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| la027549Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mps6Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| mps7Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa16389 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22413 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| um148 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| basal ganglia calcification | Alliance | Basal ganglia calcification, idiopathic, 4 | 615007 |
| infantile myofibromatosis | Alliance | Myofibromatosis, infantile, 1 | 228550 |
| Kosaki overgrowth syndrome | 616592 | ||
| Premature aging syndrome, Penttinen type | 601812 | ||
| ?Ocular pterygium-digital keloid dysplasia syndrome | 621091 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001824 | Tyrosine-protein kinase, receptor class III, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class III, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0G2L2B8 | InterPro | 877 | ||||||||||||||
| UniProtKB:D9MNA7 | InterPro | 1064 | ||||||||||||||
| UniProtKB:A0A8M9QKL5 | InterPro | 1072 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pdgfrb-201
(1)
|
Ensembl | 3,195 nt | ||
| mRNA |
pdgfrb-202
(1)
|
Ensembl | 7,594 nt |
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Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pdgfrb | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
- Wang, C., Zhong, Y., Zhang, Y., Jiang, Y., Wang, C., An, L., Luo, C., Yang, L., He, Z., Yang, Y., Luo, M., Mao, M., Wang, W., Liu, Q., Shi, Y., Ping, Y.F. (2025) Cd248a regulates pericyte development and viability in zebrafish. Communications biology. 8:451451
- Bhattarai, P., Gunasekaran, T.I., Belloy, M.E., Reyes-Dumeyer, D., Jülich, D., Tayran, H., Yilmaz, E., Flaherty, D., Turgutalp, B., Sukumar, G., Alba, C., McGrath, E.M., Hupalo, D.N., Bacikova, D., Le Guen, Y., Lantigua, R., Medrano, M., Rivera, D., Recio, P., Nuriel, T., Ertekin-Taner, N., Teich, A.F., Dickson, D.W., Holley, S., Greicius, M., Dalgard, C.L., Zody, M., Mayeux, R., Kizil, C., Vardarajan, B.N. (2024) Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease. Acta Neuropathologica. 147:7070
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Zhou, W., Ghersi, J.J., Ristori, E., Semanchik, N., Prendergast, A., Zhang, R., Carneiro, P., Baldissera, G., Sessa, W.C., Nicoli, S. (2024) Akt is a mediator of artery specification during zebrafish development. Development (Cambridge, England). 151(17):
- Zi, H., Peng, X., Cao, J., Xie, T., Liu, T., Li, H., Bu, J., Du, J., Li, J. (2024) Piezo1-dependent regulation of pericyte proliferation by blood flow during brain vascular development. Cell Reports. 43:113652113652
- Zi, H., Peng, X., Du, J., Li, J. (2024) Protocol for generating a pericyte reporter zebrafish line Ki(pdgfrb-P2A-GAL4-VP16) using a CRISPR-Cas9-mediated knockin technique. STAR protocols. 6:103490103490
- Zi, H., Peng, X., Shen, X., Chen, M., Hua, Y., Li, J., Sun, L., Li, H., Deng, Q., Du, J. (2024) Foxc1b regulates brain pericyte proliferation in zebrafish larvae. Journal of genetics and genomics = Yi chuan xue bao. 51(11):1334-1337
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Mao, A., Li, Z., Ning, G., Zhou, Z., Wei, C., Li, J., He, X., Wang, Q. (2023) Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis. Development (Cambridge, England). 150(22):
- Mizoguchi, T., Okita, M., Minami, Y., Fukunaga, M., Maki, A., Itoh, M. (2023) Age-dependent dysfunction of the cerebrovascular system in the zebrafish telencephalon. Experimental gerontology. 178:112206
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