Gene
slc17a6b
- ID
- ZDB-GENE-030616-554
- Name
- solute carrier family 17 member 6b
- Symbol
- slc17a6b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable chloride channel activity; neurotransmitter transmembrane transporter activity; and secondary active transmembrane transporter activity. Involved in visual perception. Acts upstream of or within chemical synaptic transmission. Predicted to be located in neuron projection and synaptic vesicle. Predicted to be part of chloride channel complex. Predicted to be active in excitatory synapse and synaptic vesicle membrane. Is expressed in nervous system and trigeminal placode. Orthologous to human SLC17A6 (solute carrier family 17 member 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1082 (18 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016081Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa15613 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31579 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tc257z | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-slc17a6b | Kimura et al., 2014 | |
| CRISPR2-slc17a6b | (4) | |
| MO1-slc17a6b | N/A | Bae et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Major facilitator superfamily | Major facilitator superfamily domain | Major Facilitator Superfamily Sodium/Anion Cotransporter | MFS transporter superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q5W8I8 | InterPro | 584 | ||||
| UniProtKB:Q8JFT2 | InterPro | 515 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc17a6b-201
(1)
|
Ensembl | 1,548 nt | ||
| mRNA |
slc17a6b-202
(1)
|
Ensembl | 5,680 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-slc17a6 | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(slc17a6b:LOXP-DsRed-LOXP-GFP) |
|
| 1 | (70) | |
| Tg(slc17a6b:EGFP) |
|
| 1 | (28) | |
| TgBAC(slc17a6b:GAL4FF) |
|
| 1 | (15) | |
| TgBAC(slc17a6b-hsp70l:GAL4FF) |
|
| 1 | Asakawa et al., 2023 | |
| TgBAC(slc17a6b:LOXP-DsRed-LOXP-ChRWR-GFP) |
|
| Böhm et al., 2022 | ||
| TgBAC(slc17ab:LOXP-mCherry-LOXP-GAL4FF) |
|
| 1 | (13) | |
| Tg(slc17a6b:DsRed) |
|
| 1 | (31) | |
| Tg(slc17a6b:GAL4FF) |
|
| 1 | (2) | |
| Tg(slc17a6b:LOXP-DsRed-LOXP-ChRWR-GFP) |
|
| 1 | Böhm et al., 2022 | |
| Tg(slc17a6b:MA-Tomato) |
|
| 1 | Chow et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-150G13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-46P12 | ZFIN Curated Data | |
| Contained in | PAC | XX-PACKT73 | ||
| Contained in | PAC | XX-PACKT90 | ||
| Encodes | EST | eu1082 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:193644 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128821 (1) | 1887 nt | ||
| Genomic | GenBank:AL929252 (2) | 173244 nt | ||
| Polypeptide | UniProtKB:Q5W8I8 (1) | 584 aa |
- Hu, M., Veldman, M.B. (2025) Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway. Molecular neurodegeneration. 20:2828
- Baker, C.E., Marta, A.G., Zimmerman, N.D., Korade, Z., Mathy, N.W., Wilton, D., Simeone, T., Kochvar, A., Kramer, K.L., Stessman, H.A.F., Shibata, A. (2024) CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression. Biomolecules. 14(8):
- Duan, W., Huang, G., Sui, Y., Wang, K., Yu, Y., Chu, X., Cao, X., Chen, L., Liu, J., Eichler, E.E., Xiong, B. (2024) Deficiency of DDX3X results in neurogenesis defects and abnormal behaviors via dysfunction of the Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 121:e2404173121e2404173121
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- Itoh, T., Uehara, M., Yura, S., Wang, J.C., Fujii, Y., Nakanishi, A., Shimizu, T., Hibi, M. (2024) Foxp- and Skor-family proteins control differentiation of Purkinje cells from Ptf1a and Neurogenin1-expressing progenitors in zebrafish. Development (Cambridge, England). 151(7):
- Wang, Y., Sun, X., Xiong, B., Duan, M., Sun, Y. (2024) Genetic and Environmental Factors Co-Contributing to Behavioral Abnormalities in adnp/adnp2 Mutant Zebrafish. International Journal of Molecular Sciences. 25(17):
- Asakawa, K., Handa, H., Kawakami, K. (2023) Dysregulated TDP-43 proteostasis perturbs excitability of spinal motor neurons during brainstem-mediated fictive locomotion in zebrafish. Development, growth & differentiation. 65(8):446-452
- Dogra, D., Meza-Santoscoy, P.L., Gavrilovici, C., Rehak, R., de la Hoz, C.L.R., Ibhazehiebo, K., Rho, J.M., Kurrasch, D.M. (2023) kcna1a mutant zebrafish model episodic ataxia type 1 (EA1) with epilepsy and respond to first-line therapy carbamazepine. Epilepsia. 64(8):2186-2199
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Kuil, L.E., Kakiailatu, N.J.M., Windster, J.D., Bindels, E., Zink, J.T.M., van der Zee, G., Hofstra, R.M.W., Shepherd, I.T., Melotte, V., Alves, M.M. (2023) Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level. iScience. 26:107070107070
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