Gene

hspb1

ID
ZDB-GENE-030326-4
Name
heat shock protein, alpha-crystallin-related, 1
Symbol
hspb1 Nomenclature History
Previous Names
  • hsp27 (1)
  • cb153 (1)
  • cb660 (1)
  • id:ibd2821
  • sb:cb660
  • zgc:103437
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable unfolded protein binding activity. Acts upstream of or within regulation of myofibril size; response to arsenic-containing substance; and response to heat. Located in cytoplasm and nucleus. Is expressed in several structures, including mesoderm; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; autosomal dominant distal hereditary motor neuronopathy 3; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
41 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-hspb1
    (2)
    MO1-hspb1N/A (3)
    1 - 2 of 2
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    Human Disease
    Associated With hspb1 Human Ortholog
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant distal hereditary motor neuronopathy 3 Alliance Neuronopathy, distal hereditary motor, autosomal dominant 3 608634
    Charcot-Marie-Tooth disease axonal type 2F Alliance Charcot-Marie-Tooth disease, axonal, type 2F 606595
    1 - 2 of 2
    Associated With hspb1 Via Experimental Models
    No data available
    Gene Ontology
    Protein Domains
    Domain, Family, and Site Summary
    Type InterPro ID Name
    Domain IPR002068 Alpha crystallin/Hsp20 domain
    Domain IPR037876 Heat shock protein beta-1, ACD domain
    Family IPR001436 Alpha crystallin/Small heat shock protein, animal type
    Homologous_superfamily IPR008978 HSP20-like chaperone
    1 - 4 of 4
    Domain Details Per Protein
    Protein Additional Resources Length Alpha crystallin/Hsp20 domain Alpha crystallin/Small heat shock protein, animal type Heat shock protein beta-1, ACD domain HSP20-like chaperone
    UniProtKB:A4VAK4 InterPro 199
    1 - 1 of 1
    Transcripts
    Genome Browsers
    Genome Build: GRCz11Chromosome: 5
    Type Name Annotation Method Has Havana Data Length (nt) Analysis
    mRNA hspb1-201 (1) Ensembl 1,052 nt
    mRNA hspb1-203 (1) Ensembl 498 nt
    ncRNA hspb1-002 (1) Ensembl 745 nt
    1 - 3 of 3
    Interactions and Pathways
    No data available
    Antibodies
    Name Type Antigen Genes Isotype Host Organism Assay Source Citations
    Ab1-hspb1 polyclonal
    • IHC
    • WB
    6
    1 - 1 of 1
    Plasmids
    No data available
    Constructs
    Construct Regulatory Region Coding Sequence Species Tg Lines Citations
    Tg2(hspb1:EGFP)
    • hspb1
    • Danio rerio
    1 (3)
    Tg(hspb1:EGFP)
    • hspb1
    • Danio rerio
    1 (3)
    Tg(lyz:hspb1,mCherry)
    • Danio rerio
    1 (2)
    1 - 3 of 3
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    Marker Relationships
    Relationship Marker Type Marker Accession Numbers Citations
    Contained inFosmidZFOS-631D6ZFIN Curated Data
    ContainsSTSchunp30328
    EncodesESTcb153Thisse et al., 2001
    EncodesESTcb660Thisse et al., 2001
    EncodesESTibd2821
    EncodescDNAMGC:103437ZFIN Curated Data
    EncodescDNAMGC:114088ZFIN Curated Data
    EncodescDNAMGC:192174ZFIN Curated Data
    1 - 8 of 8
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanHSPB17
    Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Phylogenetic tree (2)
    MouseHspb15
    Phylogenetic tree (1)
    Amino acid sequence comparison (1)
    Citations
    1 - 10 of 42
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