Gene
hspb1
- ID
- ZDB-GENE-030326-4
- Name
- heat shock protein, alpha-crystallin-related, 1
- Symbol
- hspb1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable unfolded protein binding activity. Acts upstream of or within regulation of myofibril size; response to arsenic-containing substance; and response to heat. Located in cytoplasm and nucleus. Is expressed in several structures, including mesoderm; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; autosomal dominant distal hereditary motor neuronopathy 3; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb660 (12 images)
- cb153 (38 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant distal hereditary motor neuronopathy 3 | Alliance | Neuronopathy, distal hereditary motor, autosomal dominant 3 | 608634 |
| Charcot-Marie-Tooth disease axonal type 2F | Alliance | Charcot-Marie-Tooth disease, axonal, type 2F | 606595 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha crystallin/Hsp20 domain | Alpha crystallin/Small heat shock protein, animal type | Heat shock protein beta-1, ACD domain | HSP20-like chaperone |
|---|---|---|---|---|---|---|
| UniProtKB:A4VAK4 | InterPro | 199 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(hspb1:EGFP) |
|
| 1 | (3) | |
| Tg(hspb1:EGFP) |
|
| 1 | (3) | |
| Tg(lyz:hspb1,mCherry) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-631D6 | ZFIN Curated Data | |
| Contains | STS | chunp30328 | ||
| Encodes | EST | cb153 | Thisse et al., 2001 | |
| Encodes | EST | cb660 | Thisse et al., 2001 | |
| Encodes | EST | ibd2821 | ||
| Encodes | cDNA | MGC:103437 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:114088 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192174 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001008615 (1) | 957 nt | ||
| Genomic | GenBank:FP017189 (2) | 33555 nt | ||
| Polypeptide | UniProtKB:A4VAK4 (1) | 199 aa |
- Luo, H., Li, Q., Hong, J., Huang, Z., Deng, W., Wei, K., Lu, S., Wang, H., Zhang, W., Liu, W. (2024) Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842. Haematologica. 109(7):2092-2110
- Hadzhiev, Y., Wheatley, L., Cooper, L., Ansaloni, F., Whalley, C., Chen, Z., Finaurini, S., Gustincich, S., Sanges, R., Burgess, S., Beggs, A., Müller, F. (2023) The miR-430 locus with extreme promoter density forms a transcription body during the minor wave of zygotic genome activation. Developmental Cell. 58:155170.e8155-170.e8
- Hong, Y., Hu, C.B., Bai, J., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2023) Essential role of an ERV-derived Env38 protein in adaptive humoral immunity against an exogenous SVCV infection in a zebrafish model. PLoS pathogens. 19:e1011222e1011222
- Sojan, J.M., Gundappa, M.K., Carletti, A., Gaspar, V., Gavaia, P., Maradonna, F., Carnevali, O. (2022) Zebrafish as a Model to Unveil the Pro-Osteogenic Effects of Boron-Vitamin D3 Synergism. Frontiers in nutrition. 9:868805
- Metikala, S., Casie Chetty, S., Sumanas, S. (2021) Single-cell transcriptome analysis of the zebrafish embryonic trunk. PLoS One. 16:e0254024
- Dubińska-Magiera, M., Niedbalska-Tarnowska, J., Migocka-Patrzałek, M., Posyniak, E., Daczewska, M. (2020) Characterization of Hspb8 in Zebrafish. Cells. 9(6):
- Han, B., Luo, J., Jiang, P., Li, Y., Wang, Q., Bai, Y., Chen, J., Wang, J., Zhang, J. (2020) Inhibition of Embryonic HSP 90 Function Promotes Variation of Cold Tolerance in Zebrafish. Frontiers in genetics. 11:541944
- Liu, R., Hu, X., Lü, A., Song, Y., Lian, Z., Sun, J., Sung, Y.Y. (2020) Proteomic Profiling of Zebrafish Challenged by Spring Viremia of Carp Virus Provides Insight into Skin Antiviral Response. Zebrafish. 17:91-103
- Rehman, S.U., Nadeem, A., Javed, M., Hassan, F.U., Luo, X., Khalid, R.B., Liu, Q. (2020) Genomic Identification, Evolution and Sequence Analysis of the Heat-Shock Protein Gene Family in Buffalo. Genes. 11(11):
- Gong, L., Zhang, Q., Pan, X., Chen, S., Yang, L., Liu, B., Yang, W., Yu, L., Xiao, Z.X., Feng, X.H., Wang, H., Yuan, Z.M., Peng, J., Tan, W.Q., Chen, J. (2019) p53 Protects Cells from Death at the Heatstroke Threshold Temperature. Cell Reports. 29:3693-3707.e5
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