Gene
ift88
- ID
- ZDB-GENE-030131-574
- Name
- intraflagellar transport 88 homolog
- Symbol
- ift88 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable kinesin binding activity. Acts upstream of or within with a positive effect on cilium assembly. Acts upstream of or within several processes, including cerebrospinal fluid circulation; photoreceptor cell maintenance; and plasma membrane bounded cell projection organization. Located in axoneme and ciliary basal body. Is expressed in forerunner cell group; head; nervous system; and pronephric duct. Orthologous to human IFT88 (intraflagellar transport 88).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 57 figures from 35 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ift88_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
sa7628 | Allele with one point mutation | Unknown | Missense | ENU | |
sa8799 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa18944 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa27381 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa41401 | Allele with one point mutation | Unknown | Splice Site | ENU | |
tz288 | Allele with one point mutation | Exon 11 | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-ift88 | Thomas et al., 2014 | |
CRISPR2-ift88 | Thomas et al., 2014 | |
CRISPR3-ift88 | Chen et al., 2017 | |
MO1-ift88 | N/A | (14) |
MO2-ift88 | N/A | (6) |
MO3-ift88 | N/A | (7) |
MO4-ift88 | N/A | (9) |
MO5-ift88 | N/A | Bisgrove et al., 2005 |
MO6-ift88 | N/A | Bisgrove et al., 2005 |
MO7-ift88 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat |
---|---|---|---|---|
UniProtKB:A0A8M9Q4H3 | InterPro | 842 | ||
UniProtKB:A0A8M9QJI0 | InterPro | 872 | ||
UniProtKB:A0A8M2BF03 | InterPro | 841 | ||
UniProtKB:A0A8M9PRW8 | InterPro | 856 | ||
UniProtKB:A0A8M2BEW9 | InterPro | 826 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(hsp70l:ift88-GFP) |
|
| 1 | Sun et al., 2024 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-51D17 | ZFIN Curated Data | |
Encodes | EST | fb37b11 | ||
Encodes | EST | zah8127 | ||
Encodes | cDNA | MGC:193654 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001001725 (1) | 2897 nt | ||
Genomic | GenBank:CR392366 (1) | 125898 nt | ||
Polypeptide | UniProtKB:A0A8M9QJI0 (1) | 872 aa |
- Boldizar, H., Friedman, A., Stanley, T., Padilla, M., Galdieri, J., Sclar, A., Stawicki, T.M. (2024) The role of cilia in the development, survival, and regeneration of hair cells. Biology Open. 13(9):
- Sun, Y., Chen, Z., Jin, M., Xie, H., Zhao, C. (2024) Ciliary length regulation by intraflagellar transport in zebrafish. eLIFE. 13:
- Xie, H., Kang, Y., Liu, J., Huang, M., Dai, Z., Shi, J., Wang, S., Li, L., Li, Y., Zheng, P., Sun, Y., Han, Q., Zhang, J., Zhu, Z., Xu, L., Yelick, P.C., Cao, M., Zhao, C. (2023) Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish. PLoS Biology. 21:e3002008e3002008
- Wang, J., Thomas, H.R., Thompson, R.G., Waldrep, S.C., Fogerty, J., Song, P., Li, Z., Ma, Y., Santra, P., Hoover, J.D., Yeo, N.C., Drummond, I.A., Yoder, B.K., Amack, J.D., Perkins, B., Parant, J.M. (2022) Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants. Disease models & mechanisms. 15(12):
- Xie, H., Wang, X., Jin, M., Li, L., Zhu, J., Kang, Y., Chen, Z., Sun, Y., Zha, C. (2022) Cilia regulate meiotic recombination in zebrafish. Journal of molecular cell biology. 14(7)
- Aparicio, G., Rodao, M., Badano, J.L., Zolessi, F.R. (2021) Photoreceptor progenitor dynamics in the zebrafish embryo retina and its modulation by primary cilia and N-cadherin. The International journal of developmental biology. 65:439-455
- Cardenas-Rodriguez, M., Austin-Tse, C., Bergboer, J.G.M., Molinari, E., Sugano, Y., Bachmann-Gagescu, R., Sayer, J.A., Drummond, I.A. (2021) Genetic compensation for cilia defects in cep290/NPHP6 mutants by upregulation of cilia-associated small GTPases. Journal of Cell Science. 134(14):
- Cheung, K.Y., Jesuthasan, S.J., Baxendale, S., van Hateren, N.J., Marzo, M., Hill, C.J., Whitfield, T.T. (2021) Olfactory Rod Cells: A Rare Cell Type in the Larval Zebrafish Olfactory Epithelium With a Large Actin-Rich Apical Projection. Frontiers in Physiology. 12:626080
- Fang, X., Peden, A.A., van Eeden, F.J.M., Malicki, J.J. (2021) Identification of additional outer segment targeting signals in zebrafish rod opsin. Journal of Cell Science. 134(6):
- Geng, F., Ma, J., Li, X., Hu, Z., Zhang, R. (2021) Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration. International Journal of Molecular Sciences. 22(8):
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