Gene
mtor
- ID
- ZDB-GENE-030131-2974
- Name
- mechanistic target of rapamycin kinase
- Symbol
- mtor Nomenclature History
- Previous Names
-
- ztor (1)
- frap1
- wu:fc22h08
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including defense response to bacterium; positive regulation of myelination; and regulation of TOR signaling. Predicted to be located in several cellular components, including PML body; bounding membrane of organelle; and phagocytic vesicle. Predicted to be part of TORC1 complex and TORC2 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; male organism; muscle; nervous system; and somite. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144752 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
cq69 | Allele with one deletion | Exon 5 | Unknown | CRISPR | |
fh178 | unknown | Unknown | Unknown | ENU | |
la016408Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa11792 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa16755 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa21374 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa30906 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa31678 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa34485 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa38710 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-mtor | (2) | |
CRISPR2-mtor | Ding et al., 2022 | |
CRISPR3-mtor | Bu et al., 2021 | |
CRISPR4-mtor | Xiao et al., 2024 | |
CRISPR5-mtor | Xia et al., 2024 | |
MO1-mtor | N/A | (7) |
MO2-mtor | N/A | Makky et al., 2007 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
Domain | IPR003151 | PIK-related kinase, FAT |
Domain | IPR003152 | FATC domain |
Domain | IPR009076 | FKBP12-rapamycin binding domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | DNA Damage Response and Repair Kinase | FATC domain | FKBP12-rapamycin binding domain | FKBP12-rapamycin binding domain superfamily | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | PIK-related kinase | PIK-related kinase, FAT | Protein kinase-like domain superfamily | Serine/threonine-protein kinase mTOR domain | Serine/threonine-protein kinase TOR, catalytic domain | Tetratricopeptide-like helical domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q06RG6 | InterPro | 2515 | |||||||||||||||
UniProtKB:A0A8M1NB07 | InterPro | 2515 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-95C6 | ZFIN Curated Data | |
Contained in | BAC | CH211-119D14 | ZFIN Curated Data | |
Contained in | BAC | CH211-220J14 | ZFIN Curated Data | |
Contained in | BAC | DKEY-75A21 | ZFIN Curated Data | |
Encodes | EST | fc22h08 | ||
Encodes | EST | IMAGE:7144752 | Thisse et al., 2004 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001077211 (1) | 8527 nt | ||
Genomic | GenBank:AL844179 (1) | 182105 nt | ||
Polypeptide | UniProtKB:A0A8M1NB07 (1) | 2515 aa |
- Della Vecchia, S., Imbrici, P., Liantonio, A., Naef, V., Damiani, D., Licitra, R., Bernardi, S., Marchese, M., Santorelli, F.M. (2025) Dapagliflozin ameliorates Lafora disease phenotype in a zebrafish model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 183:117800117800
- Gao, Y., Wu, Y., Tie, F., Wang, H. (2024) Stilbenoids from fenugreek seeds alleviate insulin resistance by regulating the PI3K/AKT/mTOR signaling pathway in a type 2 diabetes zebrafish model. Heliyon. 10:e32007e32007
- Huang, W., Yue, Y., Hao, W., Zhang, Z., Cai, P., Yang, D. (2024) mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish. Stem Cell Reports. 19(9):1277-1288
- Lin, B., Wan, H., Yang, J., Yu, L., Zhou, H., Wan, H. (2024) Lipid regulation of protocatechualdehyde and hydroxysafflor yellow A via AMPK/SREBP2/PCSK9/LDLR signaling pathway in hyperlipidemic zebrafish. Heliyon. 10:e24908e24908
- Marchese, M., Bernardi, S., Ogi, A., Licitra, R., Silvi, G., Mero, S., Galatolo, D., Gammaldi, N., Doccini, S., Ratto, G.M., Rapposelli, S., Neuhauss, S.C.F., Zang, J., Rocchiccioli, S., Michelucci, E., Ceccherini, E., Santorelli, F.M. (2024) Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model. Neurobiology of disease. 197:106536
- Pan, S.W., Wang, H.D., Hsiao, H.Y., Hsu, P.J., Tseng, Y.C., Liang, W.C., Jong, Y.J., Yuh, C.H. (2024) Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish. Scientific Reports. 14:1282612826
- Ranasinghe, T., Seo, Y., Park, H.C., Choe, S.K., Cha, S.H. (2024) Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo. Journal of hazardous materials. 480:136215136215
- Rani, R., Sri, N.S., Medishetti, R., Chatti, K., Sevilimedu, A. (2024) Loss of FMRP affects ovarian development and behaviour through multiple pathways in a zebrafish model of fragile X syndrome. Human molecular genetics. 33(16):1391-1405
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Wang, Z., Liu, Y., Hu, J., You, X., Yang, J., Zhang, Y., Liu, Q., Yang, D. (2024) Tissue-resident trained immunity in hepatocytes protects against septic liver injury in zebrafish. Cell Reports. 43:114324114324
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