Gene

mtor

ID
ZDB-GENE-030131-2974
Name
mechanistic target of rapamycin kinase
Symbol
mtor Nomenclature History
Previous Names
  • ztor (1)
  • frap1
  • wu:fc22h08
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including defense response to bacterium; positive regulation of myelination; and regulation of TOR signaling. Predicted to be located in several cellular components, including PML body; bounding membrane of organelle; and phagocytic vesicle. Predicted to be part of TORC1 complex and TORC2 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including digestive system; male organism; muscle; nervous system; and somite. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
30 figures from 23 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 11 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
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Sequence Targeting Reagents
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Human Disease
Associated With mtor Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Focal cortical dysplasia, type II, somatic 607341
Smith-Kingsmore syndrome 616638
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Associated With mtor Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Domain IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain IPR003151 PIK-related kinase, FAT
Domain IPR003152 FATC domain
Domain IPR009076 FKBP12-rapamycin binding domain
1 - 5 of 15 Show all
Domain Details Per Protein
Protein Additional Resources Length Armadillo-like helical Armadillo-type fold DNA Damage Response and Repair Kinase FATC domain FKBP12-rapamycin binding domain FKBP12-rapamycin binding domain superfamily Phosphatidylinositol 3-/4-kinase, catalytic domain Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily Phosphatidylinositol 3/4-kinase, conserved site PIK-related kinase PIK-related kinase, FAT Protein kinase-like domain superfamily Serine/threonine-protein kinase mTOR domain Serine/threonine-protein kinase TOR, catalytic domain Tetratricopeptide-like helical domain superfamily
UniProtKB:Q06RG6 InterPro 2515
UniProtKB:A0A8M1NB07 InterPro 2515
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 8
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA mtor-201 (1) Ensembl 8,454 nt
mRNA mtor-202 (1) Ensembl 8,700 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-mtor polyclonal IgG Rabbit
  • IHC
  • WB
GeneTex
6
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Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-95C6ZFIN Curated Data
Contained inBACCH211-119D14ZFIN Curated Data
Contained inBACCH211-220J14ZFIN Curated Data
Contained inBACDKEY-75A21ZFIN Curated Data
EncodesESTfc22h08
EncodesESTIMAGE:7144752Thisse et al., 2004
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanMTOR1
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseMtor4
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 93
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