Gene
ccn2a
- ID
- ZDB-GENE-030131-102
- Name
- cellular communication network factor 2a
- Symbol
- ccn2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable heparin binding activity and integrin binding activity. Acts upstream of or within with a negative effect on definitive hemopoiesis. Acts upstream of or within several processes, including cranial skeletal system development; endoderm development; and notochord development. Predicted to be located in cell periphery and extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including digestive system; fin; head; mesoderm; and spinal cord. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Li-Shao-Li type. Orthologous to human CCN2 (cellular communication network factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 28 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu936 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns50 | Allele with one deletion | Exon 3 | Frameshift, Premature Stop | TALEN | |
| el654 | Allele with one deletion | Unknown | Frameshift | CRISPR | |
| sa11839 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13699 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25135 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3090 | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondyloepimetaphyseal dysplasia, Li-Shao-Li type | Alliance | ?Spondyloepimetaphyseal dysplasia, Li-Shao-Li type | 621099 |
| Kyphomelic dysplasia | 211350 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| osteochondrodysplasia | WT + CRISPR10-ccn2a + CRISPR11-ccn2a | standard conditions | Singh et al., 2024 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CCN, TSP1 domain | Cellular Communication Network Factor | Cystine knot, C-terminal | Glycoprotein hormone subunit beta | Growth factor receptor cysteine-rich domain superfamily | IGFBP-related, CNN | Insulin-like growth factor-binding protein, IGFBP | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5RI33 | InterPro | 345 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1ccn2a:d2GFP) |
|
| 1 | (2) | |
| Tg2(ccn2a:EGFP) |
|
| 1 | (5) | |
| Tg2(hsp70l:ccn2a-2A-EGFP) |
| 1 | Mokalled et al., 2016 | ||
| Tg3(hsp70l:ccn2a-2A-EGFP) |
| 1 | Mokalled et al., 2016 | ||
| TgBAC(ccn2a:EGFP) |
|
| 1 | (3) | |
| Tg(ccn2a:mCherry-2A-NTR) |
|
| 1 | Cigliola et al., 2023 | |
| Tg(ccn2a:mCherry-NTR) |
|
| 1 | Klatt Shaw et al., 2021 | |
| Tg(ccn2a:EGFP) |
|
| 1 | (5) | |
| Tg(hsp70l:ccn2a-2A-EGFP) |
| 1 | (3) | ||
| Tg(UAS:ccn2a-EGFP) |
|
| 1 | Nagasawa-Masuda et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-266K12 | ZFIN Curated Data | |
| Encodes | EST | cegs2096 | Rauch et al., 2003 | |
| Encodes | EST | eu936 | Thisse et al., 2005 | |
| Encodes | EST | fl25c03 | ||
| Encodes | EST | zeh1559 | Ton et al., 2000 | |
| Encodes | cDNA | MGC:136644 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001015041 (1) | 2119 nt | ||
| Genomic | GenBank:BX323010 (2) | 176396 nt | ||
| Polypeptide | UniProtKB:Q5RI33 (1) | 345 aa |
- Hyland, V., Iovine, M.K. (2025) Ccn2a acts downstream of cx43 to influence joint formation during zebrafish fin regeneration. Biology Open. :
- Chen, M., Liu, Y., Zuo, M., Guo, C., Du, Y., Xu, H., Liu, B., Li, M., Xiao, W., Yu, G. (2024) NEDD8 enhances Hippo signaling by mediating YAP1 neddylation. The Journal of biological chemistry. 300(8):107512
- Gupta, S., Hui, S.P. (2024) Epigenetic Cross-Talk Between Sirt1 and Dnmt1 Promotes Axonal Regeneration After Spinal Cord Injury in Zebrafish. Molecular neurobiology. :
- Li, S., Shao, R., Li, S., Zhao, J., Deng, Q., Li, P., Wei, Z., Xu, S., Chen, L., Li, B., Zou, W., Zhang, Z. (2024) A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass. Bone research. 12:6060
- Singh, S., Danda, S., Sharma, N., Shah, H., Madhuri, V., Mir, T.A., Padala, N.Z., Medishetti, R., Ekbote, A., Bhavani, G.S., Sevilimedu, A., Girisha, K.M. (2024) Biallelic variants in CCN2 underlie an autosomal recessive kyphomelic dysplasia. European journal of human genetics : EJHG. 33(1):30-37
- Xiao, W., Hu, C., Ni, Y., Wang, J., Jiao, K., Zhou, M., Li, Z. (2024) 27-Hydroxycholesterol activates the GSK-3β/β-catenin signaling pathway resulting in intestinal fibrosis by inducing oxidative stress: effect of dietary interventions. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 73(2):289-304
- Ye, X., Lin, J., Chen, Q., Lv, J., Liu, C., Wang, Y., Wang, S., Wen, X., Lin, F. (2024) An Efficient Vector-Based CRISPR/Cas9 System in Zebrafish Cell Line. Marine biotechnology (New York, N.Y.). 26(3):588-598
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Zhu, M., Li, Y., Shen, Q., Gong, Z., Liu, D. (2024) Sex disparity in zebrafish liver cell proliferation after partial hepatectomy is regulated by sex hormone receptors and the S100A1-YAP signaling cascade. Disease models & mechanisms. 17(10):
- Celeghin, R., Risato, G., Beffagna, G., Cason, M., Bueno Marinas, M., Della Barbera, M., Facchinello, N., Giuliodori, A., Brañas Casas, R., Caichiolo, M., Vettori, A., Grisan, E., Rizzo, S., Dalla Valle, L., Argenton, F., Thiene, G., Tiso, N., Pilichou, K., Basso, C. (2023) A novel DSP zebrafish model reveals training- and drug-induced modulation of arrhythmogenic cardiomyopathy phenotypes. Cell death discovery. 9:441441
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