Gene
gapdh
- ID
- ZDB-GENE-030115-1
- Name
- glyceraldehyde-3-phosphate dehydrogenase
- Symbol
- gapdh Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; microtubule binding activity; and peptidyl-cysteine S-nitrosylase activity. Predicted to be involved in several processes, including peptidyl-cysteine S-trans-nitrosylation; positive regulation of canonical NF-kappaB signal transduction; and protein stabilization. Predicted to act upstream of or within apoptotic process and glucose metabolic process. Predicted to be located in cytoplasm; microtubule cytoskeleton; and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including cardiovascular system; integument; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDH (glyceraldehyde-3-phosphate dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 45 figures from 33 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb609 (28 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR020830 | Glyceraldehyde 3-phosphate dehydrogenase, active site |
| Domain | IPR020828 | Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain |
| Domain | IPR020829 | Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain |
| Family | IPR006424 | Glyceraldehyde-3-phosphate dehydrogenase, type I |
| Family | IPR020831 | Glyceraldehyde/Erythrose phosphate dehydrogenase family |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Glyceraldehyde 3-phosphate dehydrogenase, active site | Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain | Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain | Glyceraldehyde-3-phosphate dehydrogenase, type I | Glyceraldehyde/Erythrose phosphate dehydrogenase family | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5XJ10 | InterPro | 333 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-260G12 | ZFIN Curated Data | |
| Encodes | EST | bb02e05 | ||
| Encodes | EST | cb609 | Thisse et al., 2001 | |
| Encodes | EST | fb33a10 | ZFIN Curated Data | |
| Encodes | EST | ft80f05 | ||
| Encodes | cDNA | MGC:86789 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110724 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001115114 (1) | 1329 nt | ||
| Genomic | GenBank:CU861451 (2) | 120950 nt | ||
| Polypeptide | UniProtKB:Q5XJ10 (1) | 333 aa |
- Chen, S., Xu, J., Xiao, Y., Cai, H., Zhou, J., Cai, W., Wang, Y. (2025) Loss-of-Function of CLMP Is Associated With Congenital Short Bowel Syndrome and Impaired Intestinal Development. Clinical genetics. :
- Chen, Y., Zheng, K., Leng, Y., Zhang, Z., Li, X., Li, X., Ou, H., Wen, M., Qiu, F., Yu, H. (2025) Alleviating effect of Lactobacillus fermentum E15 on hyperlipidemia and hepatic lipid metabolism in zebrafish fed by a high-fat diet through the production of short-chain fatty acids. Frontiers in nutrition. 12:15229821522982
- Deng, L., Feng, Z., Li, X., Fan, L., Wu, X., Tavakoli, S., Zhu, Y., Ye, H., Wu, K. (2025) Exploring the potential mechanism of B-phycoerythrin on DSS-induced colitis and colitis-associated bone loss based on network pharmacology, molecular docking, and experimental validation. Scientific Reports. 15:54555455
- Kondrychyn, I., He, L., Wint, H., Betsholtz, C., Phng, L.K. (2025) Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis. eLIFE. 13:
- Liu, Y., Zhu, Y., Wang, X., Li, Y., Yang, S., Li, H., Dong, B., Wang, Z., Song, Y., Xu, J., Xue, C. (2025) Mechanisms by which Ganglioside GM1, a specific type of glycosphingolipid, ameliorates BMAA-induced neurotoxicity in early-life stage of zebrafish embryos. Food research international (Ottawa, Ont.). 200:115502115502
- Spampinato, M., Giallongo, C., Giallongo, S., Spina, E., Duminuco, A., Longhitano, L., Caltabiano, R., Salvatorelli, L., Broggi, G., Pricoco, E.P., Del Fabro, V., Dulcamare, I., DI Mauro, A.M., Romano, A., Di Raimondo, F., Li Volti, G., Palumbo, G.A., Tibullo, D. (2025) Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis. Journal of translational medicine. 23:6969
- Vaz-Rodrigues, R., Mazuecos, L., Contreras, M., González-García, A., Rafael, M., Villar, M., de la Fuente, J. (2025) Tick salivary proteins metalloprotease and allergen-like p23 are associated with response to glycan α-Gal and mycobacterium infection. Scientific Reports. 15:88498849
- Wawruszak, A., Luszczki, J., Bartuzi, D., Kalafut, J., Okon, E., Czerwonka, A., Stepulak, A. (2025) Selisistat, a SIRT1 inhibitor, enhances paclitaxel activity in luminal and triple-negative breast cancer: in silico, in vitro, and in vivo studies. Journal of enzyme inhibition and medicinal chemistry. 40:24585542458554
- Xia, X., Song, W., Zhang, F., Fan, Y., Zhang, B., Chen, X. (2025) ctdsp2 Knockout Induces Zebrafish Craniofacial Dysplasia via p53 Signaling Activation. International Journal of Molecular Sciences. 26:
- Aranda-Martínez, P., Sayed, R.K.A., Fernández-Martínez, J., Ramírez-Casas, Y., Yang, Y., Escames, G., Acuña-Castroviejo, D. (2024) Zebrafish as a Human Muscle Model for Studying Age-Dependent Sarcopenia and Frailty. International Journal of Molecular Sciences. 25(11):
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