Gene
axin2
- ID
- ZDB-GENE-000403-2
- Name
- axin 2 (conductin, axil)
- Symbol
- axin2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including I-SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in negative regulation of canonical Wnt signaling pathway. Acts upstream of or within dorsal/ventral axis specification and heart development. Predicted to be located in cytoplasm. Predicted to be part of beta-catenin destruction complex. Predicted to be active in nucleus and plasma membrane. Is expressed in several structures, including anterior neural keel; marginal blastomere; nervous system; pharyngeal arch; and pleuroperitoneal region. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in endometrial adenocarcinoma; gastrointestinal system cancer (multiple); lung cancer (multiple); and orofacial cleft. Orthologous to human AXIN2 (axin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 95 figures from 73 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:3818167 (27 images)
- eu48 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhu et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-axin2 | Bell et al., 2024 | |
| MO1-axin2 | N/A | Zhu et al., 2019 |
1 - 2 of 2
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| Oligodontia-colorectal cancer syndrome | 608615 |
1 - 2 of 2
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital heart disease | AB + MO1-axin2 | standard conditions | Zhu et al., 2019 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Axin-1/2, tankyrase-binding domain | Axin beta-catenin binding | Axin-like | DIX domain | DIX domain superfamily | RGS domain | RGS domain superfamily | RGS, subdomain 1/3 | RGS, subdomain 2 | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:P57095 | InterPro | 812 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(axin2:Venus) |
|
| 1 | (3) | |
| Tg(hsp70l:axin2-EGFP) |
|
| 1 | (2) |
1 - 2 of 2
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196B14 | ZFIN Curated Data | |
| Encodes | EST | eu48 | Thisse et al., 2005 | |
| Encodes | EST | fb37c08 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:3818167 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:111942 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195290 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131561 (1) | 3485 nt | ||
| Genomic | GenBank:BX088708 (2) | 193659 nt | ||
| Polypeptide | UniProtKB:P57095 (1) | 812 aa |
- Hyland, V., Iovine, M.K. (2025) Ccn2a acts downstream of cx43 to influence joint formation during zebrafish fin regeneration. Biology Open. :
- Sebo, D.J., Ali, I., Fetsko, A.R., Trimbach, A.A., Taylor, M.R. (2025) Activation of Wnt/β-catenin in neural progenitor cells regulates blood-brain barrier development and promotes neuroinflammation. Scientific Reports. 15:34963496
- Zhang, Y., Chen, Y., Liu, F.Y., Fu, J.W., Liu, X.X., Tan, J., Huang, O.P., Zou, Y. (2025) A rare deleterious missense mutation in the AXIN2 gene in Chinese women with polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 41:24635452463545
- Bell, I., Khan, H., Stutt, N., Horn, M., Hydzik, T., Lum, W., Rea, V., Clapham, E., Hoeg, L., Van Raay, T.J. (2024) Nkd1 functions downstream of Axin2 to attenuate Wnt signaling. Molecular biology of the cell. 35(7):ar93
- Camacho-Macorra, C., Tabanera, N., Sánchez-Bustamante, E., Bovolenta, P., Cardozo, M.J. (2024) Maternal vgll4a regulates zebrafish epiboly through Yap1 activity. Frontiers in cell and developmental biology. 12:13626951362695
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Coppola, U., Saha, B., Kenney, J., Waxman, J.S. (2024) A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish. PLoS Genetics. 20:e1011222e1011222
- McCann, T., Sundaramurthi, H., Walsh, C., Virdi, S., Alvarez, Y., Sapetto-Rebow, B., Collery, R.F., Carter, S.P., Moran, A., Mulholland, R., O'Connor, J.J., Taylor, M.R., Rauch, N., Starostik, M.R., English, M.A., Swaroop, A., Geisler, R., Reynolds, A.L., Kennedy, B.N. (2024) Emc1 is essential for vision and zebrafish photoreceptor outer segment morphogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e70086e70086
- Miao, D., Ren, J., Jia, Y., Jia, Y., Li, Y., Huang, H., Gao, R. (2024) PAX1 represses canonical Wnt signaling pathway and plays dual roles during endoderm differentiation. Cell communication and signaling : CCS. 22:242242
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
1 - 10 of 195
Show