FIGURE

Fig. 7

ID

ZDB-FIG-260722-8

Publication

Roussange et al., 2026 - Integrative analysis of drug-gene signatures in human pluripotent stem cells reveals prazosin as a novel SQSTM1 regulator for ALS therapeutics

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Prazosin alleviates the motor phenotype induced by sqstm1 knockdown in zebrafish
(A) Schematic illustration of zebrafish treatment and functional assessment.

(B) Quantification of swimming parameters in embryos injected with control or sqstm1-specific AMO, either untreated or treated with prazosin for 3 days, using a ViewPoint system. The qualitative scores ranged from 0 to 5. Data are presented as mean ± SEM from three independent experiments. Statistical significance was determined using the chi-square test for contingency data. ^∗∗∗∗p ≤ 0.0001.

(C) Representative western blot images and corresponding quantification of SQSTM1 and ACTB expression in embryos injected with control or sqstm1-specific AMO, with or without prazosin treatment for 3 days. Data are presented as mean ± SEM from four technical replicates. Statistical significance was determined using one-way ANOVA with Dunnett’s post hoc test and Student’s t test. ^∗p ≤ 0.05.

Expression Data

Gene:	sqstm1
Fish:	WT WT + MO3-sqstm1 + MO4-sqstm1
Condition:	chemical treatment by environment: prazosin
Knockdown Reagents:	MO3-sqstm1 MO4-sqstm1
Anatomical Term:	whole organism
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Stem Cell Reports