FIGURE

Fig. 3

ID

ZDB-FIG-250717-28

Publication

Charng et al., 2025 - Rare missense variants in FNDC1 are associated with severe adolescent idiopathic scoliosis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

The fndc1 nonsense allele (fndc1 sa23734) is associated with increased bone mineral density and total vertebral cross-sectional area in zebrafish. (A) MicroCT scan images demonstrating 3D projections of the vertebra of an individual fish. Vertebra in a lateral plane (top left) and axial plane (bottom left). Total vertebral cross-sectional area is quantified by determining the area of each axial section (right). MicroCT scans of zebrafish (n=5 for each genotype) revealed that fndc1 mutants have (B) increased vertebral bone mineral density (fndc1 +/+ vs fndc1 +/sa23734: p=0.034; fndc1 +/sa23734 vs fndc1 sa23734/sa23734: p=0.00019; fndc1 +/+ vs fndc1 sa23734/sa23734: p=6.08E-06) and (C) increased vertebral cross-sectional area compared with wild-type siblings (fndc1 +/+ vs fndc1 +/sa23734: p=0.0011; fndc1 +/sa23734 vs fndc1 sa23734/sa23734: p=0.94; fndc1 +/+ vs fndc1 sa23734/sa23734: p=1.37E-05). P values were calculated using the Wilcoxon rank-sum test, two sided. * indicates p< 0.05, ** for p < 0.005, *** for p<0.0005, and **** for p < 0.00005.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fndc1^{sa23734/sa23734} fndc1^sa23734/+
Observed In:	vertebra
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Med. Genet.