FIGURE

Figure 1

ID

ZDB-FIG-250519-1

Publication

Munro et al., 2025 - Deoxynucleoside supplementation ameliorates the disease associated phenotypes in a zebrafish model of RRM2B mtDNA depletion syndrome

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Figure 1

Mutagenesis of zebrafish rrm2b –. (A) Summary schematic depicting the rrm2b sgRNA target site on exon 3 of the zebrafish rrm2b gene. (B) DNA and corresponding peptide sequence of WT zebrafish rrm2b and mutant zebrafish rrm2b^∆26bp. Red = mutation, ^* = premature stop codon. (C) Immunoblotting of Rrm2b and alpha tubulin in rrm2b^+/+ and rrm2b^−/− in 5 dpf tail muscle. N = 10 larvae tails each. D. Quantification of Rrm2b immunoblotting relative to alpha tubulin.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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