FIGURE

Fig. 3

ID

ZDB-FIG-250313-60

Publication

Kalyn et al., 2024 - Differential roles of NR4A2 (NURR1) paralogs in the brain and behavior of zebrafish

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Fig. 3

nr4a2 response following MPTP-induced neurodegeneration. (a–g) Relative gene expression is also provided for markers of regeneration, neurogenesis, DAnergic transcription, and synthesis throughout recovery in larvae (n = 3 pools of 7 larvae). One-way ANOVA: DF: Within group = 12, between groups =2. a: F = 0.9196, p = 0.3565. b: F = 26.39, p = 0.0002; c: F = 0.3415, p = 0.5698; d: F = 14.24, p = 0.0027; e: F = 3.335, p = 0.0928; f: F = 0.6289, p = 0.4432 g: F = 11.24, p = 0.0057. (h–i) Total distance traveled and average velocity of MPTP-treated and NTC control from 0- to 5dpt (n = 30). Multiple paired t tests. h: DF, 31,53, 80; t value: 2.5722; 1.6243; 0.3756, p: 0.01512; 0.1103; 0.7082; I: DF: 31, 53, 66, t values: 7.9286; 2.1412; 3.2482; p ≤ 0.000001; 0.0369; 0.0018. (j) Representative path images. Bars represent the Mean ± the SEM. **p < 0.01, ***p < 0.001, ****p < 0.0001.

Expression Data

Genes:	nes notch1a nr4a2a nr4a2b shha slc6a3 th (all 7)
Fish:	WT
Condition:	chemical treatment by environment: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Anatomical Term:	whole organism
Stage Range:	Days 7-13 to Days 14-20

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment by environment: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Observed In:	whole organism whole organism swimming
Stage Range:	Days 7-13 to Days 14-20

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Neurochem.