Gene
slc6a3
- ID
- ZDB-GENE-010316-1
- Name
- solute carrier family 6 member 3
- Symbol
- slc6a3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity and symporter activity. Predicted to be involved in amino acid transport and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in female organism; male organism; and nervous system. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; classic dopamine transporter deficiency syndrome; mild cognitive impairment; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 75 figures from 62 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| classic dopamine transporter deficiency syndrome | Alliance | Parkinsonism-dystonia, infantile, 1 | 613135 |
| {Nicotine dependence, protection against} | 188890 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Sodium:neurotransmitter symporter | Sodium:neurotransmitter symporter superfamily |
|---|---|---|---|---|
| UniProtKB:Q90ZV1 | InterPro | 629 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc6a3-201
(1)
|
Ensembl | 1,890 nt |
Interactions and Pathways
No data available
Plasmids