Gene
slc6a3
- ID
- ZDB-GENE-010316-1
- Name
- solute carrier family 6 member 3
- Symbol
- slc6a3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity and symporter activity. Predicted to be involved in amino acid transport and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in female organism; male organism; and nervous system. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; classic dopamine transporter deficiency syndrome; mild cognitive impairment; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 75 figures from 62 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| classic dopamine transporter deficiency syndrome | Alliance | Parkinsonism-dystonia, infantile, 1 | 613135 |
| {Nicotine dependence, protection against} | 188890 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Sodium:neurotransmitter symporter | Sodium:neurotransmitter symporter superfamily |
|---|---|---|---|---|
| UniProtKB:Q90ZV1 | InterPro | 629 |
1 - 1 of 1
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc6a3-201
(1)
|
Ensembl | 1,890 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
- Nies, Y.H., Lim, W.L., Abd Karim, N., Yahaya, M.F., Teoh, S.L. (2025) Metallothionein II treatment mitigates rotenone-induced neurodegeneration in zebrafish models of Parkinson's disease. Frontiers in pharmacology. 16:14780131478013
- Tagkalidou, N., Stevanović, M., Romero-Alfano, I., Elizalde-Velázquez, G.A., Herrera-Vázquez, S.E., Prats, E., Gómez-Canela, C., Gómez-Oliván, L.M., Raldúa, D. (2025) Motor and Non-Motor Effects of Acute MPTP in Adult Zebrafish: Insights into Parkinson's Disease. International Journal of Molecular Sciences. 26:
- Bagwell, E., Shin, M., Henkel, N., Migliaccio, D., Peng, C., Larsen, J. (2024) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated adult zebrafish as a model for Parkinson's Disease. Neuroscience letters. 842:137991
- Baker, C.E., Marta, A.G., Zimmerman, N.D., Korade, Z., Mathy, N.W., Wilton, D., Simeone, T., Kochvar, A., Kramer, K.L., Stessman, H.A.F., Shibata, A. (2024) CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression. Biomolecules. 14(8):
- Correia, D., Bellot, M., Goyenechea, J., Prats, E., Moro, H., Gómez-Canela, C., Bedrossiantz, J., Tagkalidou, N., Ferreira, C.S.S., Raldúa, D., Domingues, I., Faria, M., Oliveira, M. (2024) Parental exposure to antidepressants has lasting effects on offspring? A case study with zebrafish. Chemosphere. 355:141851
- Duan, W., Huang, G., Sui, Y., Wang, K., Yu, Y., Chu, X., Cao, X., Chen, L., Liu, J., Eichler, E.E., Xiong, B. (2024) Deficiency of DDX3X results in neurogenesis defects and abnormal behaviors via dysfunction of the Notch signaling. Proceedings of the National Academy of Sciences of the United States of America. 121:e2404173121e2404173121
- Hedayatikatouli, F., Kalyn, M., Elsaid, D., Mbesha, H.A., Ekker, M. (2024) Neuroprotective Effects of Ascorbic Acid, Vanillic Acid, and Ferulic Acid in Dopaminergic Neurons of Zebrafish. Biomedicines. 12(11):
- Kalyn, M., Garvey, R., Lee, H., Mbesha, H.A., Curry, J., Saxena, V., Mennigen, J.A., Ekker, M. (2024) Differential roles of NR4A2 (NURR1) paralogs in the brain and behavior of zebrafish. Journal of neurochemistry. :
- Ranasinghe, T., Seo, Y., Park, H.C., Choe, S.K., Cha, S.H. (2024) Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo. Journal of hazardous materials. 480:136215136215
- Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576
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