FIGURE

Fig. 1

ID

ZDB-FIG-250124-38

Publication

Gries et al., 2024 - Aurora kinase B is required for growth and expansion of medulloblastoma cells in the tissue context

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Fig. 1

Blockade of collagen I invasion by Aurora and BCR-ABL/SRC kinase inhibitors. A) Left: X/Y plot of Z-score and Z-score SD of hit list. Right: Validation of selected drugs using SIA and aCDc software[14] showing mean distances of invasion from center of spheroids and SD (n=3 biological replicas). Purple: AURKBi, red: BCR-ABL/SRC inhibitors, all tested at 3 µM. B) Representation of top 60 and top 20 candidates across kinase inhibitor families. C) IB using antibodies specific for the phosphorylation of the active sites of SRC, and aurora kinase A and B proteins. Cyclin B1 protein expression confirms cell proliferation. D) Heat-map of mean values of anti-invasion efficacy of selected kinase inhibitors of SIA shown in A). E) Heat-map of mean cell viability in ONS-76 cells. F) Heat-map of cytotoxicity in ONS-76 cells. (D – E: n=3 biological replicas).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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